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Table 5 Results of Cox multivariate analysis

From: PIK3R1 underexpression is an independent prognostic marker in breast cancer

Variables Total population ER-positive patients ER-negative patients PR-positive patients PR-negative patients ERBB2-positive patients ERBB2-negative patients
  HR (95% CI)a P-valueb HR (95% CI)a P-valueb HR (95% CI)a P-valueb HR (95% CI)a P-valueb HR (95% CI)a P-valueb HR (95% CI)a P-valueb HR (95% CI)a P-valueb
SBR               
I 1 0.041 1 0.018   NS 1 0.00068   NS   NS 1 0.0034
II 1.27 (1.01-1.61) 1.42 (1.06-1.90)   1.87 (1.30-2.68)    1.49 (1.14-1.95)
III 1.62 (1.02-2.59) 2.02 (1.13-3.61)   3.49 (1.70-7.17)    2.23 (1.31-3.82)
pN               
0 1 0.00021 1 0.0024 1 0.02 1 0.0097 1 0.0055 1 0.0000076   NS
1-3 1.54 (1.22-1.93) 1.53 (1.16-2.01) 1.61 (1.08-2.40) 1.57 (1.12-2.22) 1.53 (1.13-2.07) 2.91 (1.82-4.64)  
>3 2.36 (1.50-3.72) 2.34 (1.35-4.04) 2.58 (1.16-5.74) 2.47 (1.24-4.91) 2.34 (1.28-4.28) 8.47 (3.32-21.57)  
pT               
≤25 mm 1 0.004 1 0.00014   NS 1 0.00096   NS   NS 1 0.00034
>25 mm 1.62 (1.17-2.24) 2.16 (1.45-3.20)   2.22 (1.38-3.55)    1.97 (1.36-2.86)
ER     -   -         
Negative   NS     NS   NS   NS   NS
Positive        
PR         -   -     
Negative   NS   NS   NS     NS   NS
Positive        
ERBB2             -   -
Negative   NS   NS   NS   NS   NS   
Positive        
PIK3R1               
Underexpression 1 0.0013 1 0.0076   NS 1 0.043   NS 1 0.018 1 0.024
Normal 0.59 (0.43-0.81) 0.62 (0.44-0.88)   0.65 (0.43-0.99)   0.40 (0.19-0.85) 0.66 (0.46-0.95)
Overexpression 0.35 (0.18-0.66) 0.38 (0.19-0.77)   0.42 (0.18-0.97)   0.16 (0.03-0.73) 0.44 (0.21-0.89)
PI3KCA               
Normal   NS   NS   NS   NS   NS 1 0.051   NS
Mutated       0.39 (0.15-1.00)  
  1. aHazard ratio (95% Confidential Interval). NS: not significant.
  2. bMultivariate Cox analysis. NS: not significant.
  3. The bold numbers stress important finding or overall characterisation of a group or p-value.