From: PIK3R1 underexpression is an independent prognostic marker in breast cancer
Variables | Total population | ER-positive patients | ER-negative patients | PR-positive patients | PR-negative patients | ERBB2-positive patients | ERBB2-negative patients | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI)a | P-valueb | HR (95% CI)a | P-valueb | HR (95% CI)a | P-valueb | HR (95% CI)a | P-valueb | HR (95% CI)a | P-valueb | HR (95% CI)a | P-valueb | HR (95% CI)a | P-valueb | |
SBR | ||||||||||||||
I | 1 | 0.041 | 1 | 0.018 | NS | 1 | 0.00068 | NS | NS | 1 | 0.0034 | |||
II | 1.27 (1.01-1.61) | 1.42 (1.06-1.90) | 1.87 (1.30-2.68) | 1.49 (1.14-1.95) | ||||||||||
III | 1.62 (1.02-2.59) | 2.02 (1.13-3.61) | 3.49 (1.70-7.17) | 2.23 (1.31-3.82) | ||||||||||
pN | ||||||||||||||
0 | 1 | 0.00021 | 1 | 0.0024 | 1 | 0.02 | 1 | 0.0097 | 1 | 0.0055 | 1 | 0.0000076 | NS | |
1-3 | 1.54 (1.22-1.93) | 1.53 (1.16-2.01) | 1.61 (1.08-2.40) | 1.57 (1.12-2.22) | 1.53 (1.13-2.07) | 2.91 (1.82-4.64) | ||||||||
>3 | 2.36 (1.50-3.72) | 2.34 (1.35-4.04) | 2.58 (1.16-5.74) | 2.47 (1.24-4.91) | 2.34 (1.28-4.28) | 8.47 (3.32-21.57) | ||||||||
pT | ||||||||||||||
≤25 mm | 1 | 0.004 | 1 | 0.00014 | NS | 1 | 0.00096 | NS | NS | 1 | 0.00034 | |||
>25 mm | 1.62 (1.17-2.24) | 2.16 (1.45-3.20) | 2.22 (1.38-3.55) | 1.97 (1.36-2.86) | ||||||||||
ER | - | - | ||||||||||||
Negative | NS | NS | NS | NS | NS | |||||||||
Positive | ||||||||||||||
PR | - | - | ||||||||||||
Negative | NS | NS | NS | NS | NS | |||||||||
Positive | ||||||||||||||
ERBB2 | - | - | ||||||||||||
Negative | NS | NS | NS | NS | NS | |||||||||
Positive | ||||||||||||||
PIK3R1 | ||||||||||||||
Underexpression | 1 | 0.0013 | 1 | 0.0076 | NS | 1 | 0.043 | NS | 1 | 0.018 | 1 | 0.024 | ||
Normal | 0.59 (0.43-0.81) | 0.62 (0.44-0.88) | 0.65 (0.43-0.99) | 0.40 (0.19-0.85) | 0.66 (0.46-0.95) | |||||||||
Overexpression | 0.35 (0.18-0.66) | 0.38 (0.19-0.77) | 0.42 (0.18-0.97) | 0.16 (0.03-0.73) | 0.44 (0.21-0.89) | |||||||||
PI3KCA | ||||||||||||||
Normal | NS | NS | NS | NS | NS | 1 | 0.051 | NS | ||||||
Mutated | 0.39 (0.15-1.00) |