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Table 5 Results of Cox multivariate analysis

From: PIK3R1 underexpression is an independent prognostic marker in breast cancer

Variables

Total population

ER-positive patients

ER-negative patients

PR-positive patients

PR-negative patients

ERBB2-positive patients

ERBB2-negative patients

 

HR (95% CI)a

P-valueb

HR (95% CI)a

P-valueb

HR (95% CI)a

P-valueb

HR (95% CI)a

P-valueb

HR (95% CI)a

P-valueb

HR (95% CI)a

P-valueb

HR (95% CI)a

P-valueb

SBR

              

I

1

0.041

1

0.018

 

NS

1

0.00068

 

NS

 

NS

1

0.0034

II

1.27 (1.01-1.61)

1.42 (1.06-1.90)

 

1.87 (1.30-2.68)

  

1.49 (1.14-1.95)

III

1.62 (1.02-2.59)

2.02 (1.13-3.61)

 

3.49 (1.70-7.17)

  

2.23 (1.31-3.82)

pN

              

0

1

0.00021

1

0.0024

1

0.02

1

0.0097

1

0.0055

1

0.0000076

 

NS

1-3

1.54 (1.22-1.93)

1.53 (1.16-2.01)

1.61 (1.08-2.40)

1.57 (1.12-2.22)

1.53 (1.13-2.07)

2.91 (1.82-4.64)

 

>3

2.36 (1.50-3.72)

2.34 (1.35-4.04)

2.58 (1.16-5.74)

2.47 (1.24-4.91)

2.34 (1.28-4.28)

8.47 (3.32-21.57)

 

pT

              

≤25 mm

1

0.004

1

0.00014

 

NS

1

0.00096

 

NS

 

NS

1

0.00034

>25 mm

1.62 (1.17-2.24)

2.16 (1.45-3.20)

 

2.22 (1.38-3.55)

  

1.97 (1.36-2.86)

ER

   

-

 

-

        

Negative

 

NS

   

NS

 

NS

 

NS

 

NS

Positive

       

PR

       

-

 

-

    

Negative

 

NS

 

NS

 

NS

   

NS

 

NS

Positive

       

ERBB2

           

-

 

-

Negative

 

NS

 

NS

 

NS

 

NS

 

NS

  

Positive

       

PIK3R1

              

Underexpression

1

0.0013

1

0.0076

 

NS

1

0.043

 

NS

1

0.018

1

0.024

Normal

0.59 (0.43-0.81)

0.62 (0.44-0.88)

 

0.65 (0.43-0.99)

 

0.40 (0.19-0.85)

0.66 (0.46-0.95)

Overexpression

0.35 (0.18-0.66)

0.38 (0.19-0.77)

 

0.42 (0.18-0.97)

 

0.16 (0.03-0.73)

0.44 (0.21-0.89)

PI3KCA

              

Normal

 

NS

 

NS

 

NS

 

NS

 

NS

1

0.051

 

NS

Mutated

     

0.39 (0.15-1.00)

 
  1. aHazard ratio (95% Confidential Interval). NS: not significant.
  2. bMultivariate Cox analysis. NS: not significant.
  3. The bold numbers stress important finding or overall characterisation of a group or p-value.