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Table 3 Comparison of PIK3R1 expression status and alterations of other genes of interest

From: PIK3R1 underexpression is an independent prognostic marker in breast cancer

   Number of patients (%)  
Total population (%) PIK3R1underexpression PIK3R1non-underexpression P-value a
Total 458 (100.0) 283 (61.8) 175 (38.2)  
EGFR values: median [range] 0.2 (0.0-112.9) 0.1 (0.0-7.3) 0.2 (0.0-112.9)  
Underexpressed tumors (%) 389 (84.9) 250 (88.3) 139 (79.4) 0.0096
Non-underexpressed tumors (%) 69 (15.1) 33 (11.7) 36 (20.6)
PDK1 values: median [range] 1.0 (0.0-14.7) 1.2 (0.1-14.7) 0.9 (0.0-6.2)  
Underexpressed tumors (%) 61 (13.3) 26 (9.2) 35 (20.0) 0.000004
Normally expressed tumors (%) 316 (69.0) 189 (66.8) 127 (72.6)
Overexpressed tumors (%) 81 (17.7) 68 (24.0) 13 (7.4)
AKT1 values: median [range] 1.5 (0.0-11.1) 1.4 (0.4-10.0) 1.6 (0.0-11.1)  
Non-overexpressed tumors (%) 342 (74.7) 216 (76.3) 126 (72.0) NS
Overexpressed tumors (%) 116 (25.3) 67 (23.7) 49 (28.0)
AKT2 values: median [range] b 1.0 (0.7-2.3) 1.6 (0.5-10.6) 1.8 (0.5-12.2)  
Non-overexpressed tumors (%) 293 (64.3) 189 (67.0) 104 (59.8) NS
Overexpressed tumors (%) 163 (35.7) 93 (33.0) 70 (40.2)
AKT3 values: median [range] b 1.0 (0.4-1.9) 0.3 (0.0-2.4) 0.5 (0.1-7.5)  
Underexpressed tumors (%) 306 (67.1) 215 (76.2) 91 (52.3) 0.00000013
Non-underexpressed tumors (%) 150 (32.9) 67 (23.8) 83 (47.7)
GOLPH3 values: median [range] 1.4 (0.3-6.7) 1.3 (0.3-5.2) 1.7 (0.7-6.7)  
Non-overexpressed tumors (%) 369 (80.6) 242 (85.5) 127 (72.6) 0.00067
Overexpressed tumors (%) 89 (19.4) 41 (14.5) 48 (27.4)
P70S6K values: median [range] 1.2 (0.0-19.6) 1.2 (0.4-19.6) 1.2 (0.0-8.9)  
Non-overexpressed tumors (%) 375 (81.9) 226 (79.9) 149 (85.1) NS
Overexpressed tumors (%) 83 (18.1) 57 (20.1) 26 (14.9)
WEE1 values: median [range] 0.8 (0.2-6.9) 0.7 (0.2-4.1) 0.9 (0.2-6.9)  
Underexpressed tumors (%) 84 (18.3) 68 (24.0) 16 (9.1) 0.000063
Non-underexpressed tumors (%) 374 (81.7) 215 (76.0) 159 (90.9)
PTEN values: median [range] 0.8 (0.1-9.0) 0.7 (0.1-9.0) 1.0 (0.4-5.8)  
Underexpressed tumors (%) 78 (17.0) 71 (25.1) 7 (4.0) < 0.0000001
Non-underexpressed tumors (%) 380 (83.0) 212 (74.9) 168 (96.0)
PIK3CA     
Wild-type (%) 307 (67.0) 205 (72.4) 102 (58.3) 0.0017
Mutation (%) 151 (33.0) 78 (27.6) 73 (41.7)
PIK3R1 c     
Wild-type (%) 444 (97.8) 276 (98.6) 168 (96.6) NS
Mutation (%) 10 (2.2) 4 (1.4) 6 (3.4)
AKT1 d     
Wild-type (%) 442 (96.7) 272 (96.5) 170 (97.1) NS
Mutation (%) 15 (3.3) 10 (3.5) 5 (2.9)
  1. aChi2 test. NS: not significant.
  2. bData available in 456 samples.
  3. cData available in 454 samples.
  4. dData available in 457 samples.
  5. The bold numbers stress important finding or overall characterisation of a group or p-value.