Table 3 Comparison of PIK3R1 expression status and alterations of other genes of interest
From: PIK3R1 underexpression is an independent prognostic marker in breast cancer
Number of patients (%) | ||||
|---|---|---|---|---|
Total population (%) | PIK3R1underexpression | PIK3R1non-underexpression | P-value a | |
Total | 458 (100.0) | 283 (61.8) | 175 (38.2) | |
EGFR values: median [range] | 0.2 (0.0-112.9) | 0.1 (0.0-7.3) | 0.2 (0.0-112.9) | |
Underexpressed tumors (%) | 389 (84.9) | 250 (88.3) | 139 (79.4) | 0.0096 |
Non-underexpressed tumors (%) | 69 (15.1) | 33 (11.7) | 36 (20.6) | |
PDK1 values: median [range] | 1.0 (0.0-14.7) | 1.2 (0.1-14.7) | 0.9 (0.0-6.2) | |
Underexpressed tumors (%) | 61 (13.3) | 26 (9.2) | 35 (20.0) | 0.000004 |
Normally expressed tumors (%) | 316 (69.0) | 189 (66.8) | 127 (72.6) | |
Overexpressed tumors (%) | 81 (17.7) | 68 (24.0) | 13 (7.4) | |
AKT1 values: median [range] | 1.5 (0.0-11.1) | 1.4 (0.4-10.0) | 1.6 (0.0-11.1) | |
Non-overexpressed tumors (%) | 342 (74.7) | 216 (76.3) | 126 (72.0) | NS |
Overexpressed tumors (%) | 116 (25.3) | 67 (23.7) | 49 (28.0) | |
AKT2 values: median [range] b | 1.0 (0.7-2.3) | 1.6 (0.5-10.6) | 1.8 (0.5-12.2) | |
Non-overexpressed tumors (%) | 293 (64.3) | 189 (67.0) | 104 (59.8) | NS |
Overexpressed tumors (%) | 163 (35.7) | 93 (33.0) | 70 (40.2) | |
AKT3 values: median [range] b | 1.0 (0.4-1.9) | 0.3 (0.0-2.4) | 0.5 (0.1-7.5) | |
Underexpressed tumors (%) | 306 (67.1) | 215 (76.2) | 91 (52.3) | 0.00000013 |
Non-underexpressed tumors (%) | 150 (32.9) | 67 (23.8) | 83 (47.7) | |
GOLPH3 values: median [range] | 1.4 (0.3-6.7) | 1.3 (0.3-5.2) | 1.7 (0.7-6.7) | |
Non-overexpressed tumors (%) | 369 (80.6) | 242 (85.5) | 127 (72.6) | 0.00067 |
Overexpressed tumors (%) | 89 (19.4) | 41 (14.5) | 48 (27.4) | |
P70S6K values: median [range] | 1.2 (0.0-19.6) | 1.2 (0.4-19.6) | 1.2 (0.0-8.9) | |
Non-overexpressed tumors (%) | 375 (81.9) | 226 (79.9) | 149 (85.1) | NS |
Overexpressed tumors (%) | 83 (18.1) | 57 (20.1) | 26 (14.9) | |
WEE1 values: median [range] | 0.8 (0.2-6.9) | 0.7 (0.2-4.1) | 0.9 (0.2-6.9) | |
Underexpressed tumors (%) | 84 (18.3) | 68 (24.0) | 16 (9.1) | 0.000063 |
Non-underexpressed tumors (%) | 374 (81.7) | 215 (76.0) | 159 (90.9) | |
PTEN values: median [range] | 0.8 (0.1-9.0) | 0.7 (0.1-9.0) | 1.0 (0.4-5.8) | |
Underexpressed tumors (%) | 78 (17.0) | 71 (25.1) | 7 (4.0) | < 0.0000001 |
Non-underexpressed tumors (%) | 380 (83.0) | 212 (74.9) | 168 (96.0) | |
PIK3CA | ||||
Wild-type (%) | 307 (67.0) | 205 (72.4) | 102 (58.3) | 0.0017 |
Mutation (%) | 151 (33.0) | 78 (27.6) | 73 (41.7) | |
PIK3R1 c | ||||
Wild-type (%) | 444 (97.8) | 276 (98.6) | 168 (96.6) | NS |
Mutation (%) | 10 (2.2) | 4 (1.4) | 6 (3.4) | |
AKT1 d | ||||
Wild-type (%) | 442 (96.7) | 272 (96.5) | 170 (97.1) | NS |
Mutation (%) | 15 (3.3) | 10 (3.5) | 5 (2.9) | |