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Table 2 The levels of interaction between the identified proteins and RKIP that located in the RKIP-interaction protein network diagrams (Figure 5 ), analyzed with the VisANT 3.8.6 protein-network analysis package

From: Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line

UniProt ID Protein name MiMI Functional linage network Predictome
P46940 Ras GTPase-activating-like protein IQGAP1 1st 1st 1st
P08238* Heat shock protein HSP 90-beta 2 nd 1 st 1 st
Q14974 Importin subunit beta-1 1st 2nd 1st
P11142 Heat shock cognate 71 kDa protein 1st 1st 2nd
P14618 Pyruvate kinase isozymes M1/M2 1st 1st 1st
P06576 ATP synthase subunit alpha, mitochondrial 1st 1st 1st
P07437 Tubulin beta chain 1st 3rd 1st
P68104 Elongation factor 1-alpha 1 1st 1st 1st
P60709 Actin, cytoplasmic 1 1st 1st 2nd
P05783 Keratin, type I cytoskeletal 18 1st 2nd 2nd
Q15149 Plectin 1st 2nd 1st
P21796 Voltage-dependent anion-selective channel protein 1 1st 1st 1st
P23396 40S ribosomal protein S3 1st 2nd 1st
P63244 Guanine nucleotide-binding protein subunit beta-2-like 1 1st 2nd 2nd
Q00610 Clathrin heavy chain 1 1st 1st 1st
P41252 Isoleucyl-tRNA synthetase, cytoplasmic 1st 1st 1st
P60842 Eukaryotic initiation factor 4A-I 2nd 1st 1st
P04075 Fructose-bisphosphate aldolase A 2nd 1st 2nd
P52907 F-actin-capping protein subunit alpha-1 2nd 1st 1st
P04406 Glyceraldehyde-3-phosphate dehydrogenase 2nd 3rd 2nd
P07195 L-lactate dehydrogenase B chain 2nd 1st 2nd
P04083 Annexin A1 2nd 1st 2nd
P00338 L-lactate dehydrogenase A chain 2nd 1st 3rd
P62258* 14-3-3 protein epsilon 2 nd 1 st 1 st
P26640 Valyl-tRNA synthetase 2nd 1st 2nd
P08670 Vimentin 2nd 1st 2nd
P35579 Myosin-9 2nd 1st 1st
P18206 Vinculin 2nd 3rd 2nd
P13639 Elongation factor 2 2nd 1st 1st
P07900 Heat shock protein HSP 90-alpha 2nd 1st 1st
P38646 Stress-70 protein, mitochondrial 2nd 1st 2nd
P10809 60 kDa heat shock protein, mitochondrial 2nd 1st 1st
P05787* Keratin, type II cytoskeletal 8 2 nd 2 nd 1 st
P06733 Alpha-enolase 2nd 3rd 1st
P26641 Elongation factor 1-gamma 2nd 2nd 1st
Q15029 small nuclear ribonucleoprotein component 3rd 1st 1st
P08195 4 F2 cell-surface antigen heavy chain 3rd 2nd 2nd
P53396 ATP-citrate synthase 3rd 1st 1st
O75369 Filamin-B 3rd 2nd 1st
P53992 Protein transport protein Sec24C 3rd 2nd 1st
P53618 Coatomer subunit beta 3rd 3rd 3rd
P14625 Endoplasmin 3rd 1st 1st
Q13263 Transcription intermediary factor 1-beta 3rd 2nd 1st
P02786 Transferrin receptor protein 1 3rd 3rd 1st
P55072 Transitional endoplasmic reticulum ATPase 3rd 1st 1st
O43390 Heterogeneous nuclear ribonucleoprotein R 3rd 2nd 3rd
P68371 Tubulin beta-2C chain 3rd 2nd 1st
P50454 Serpin H1 3rd 1st 1st
P00558 Phosphoglycerate kinase 1 3rd 1st 1st
P50395 Rab GDP dissociation inhibitor beta 3rd 1st 2nd
P40926 Malate dehydrogenase, mitochondrial 3rd 2nd 1st
Q99623 Prohibitin-2 3rd 2nd 3rd
P12429 Annexin A3 3rd 1st 3rd
P08758 Annexin A5 3rd 1st 3rd
O00299 Chloride intracellular channel protein 1 3rd 2nd 1st
P61289 Proteasome activator complex subunit 3 3rd 1st 1st
P09211 Glutathione S-transferase P 3rd 3rd 1st
Q06830 Peroxiredoxin-1 3rd 2nd 1st
P61026 Ras-related protein Rab-10 3rd 3rd 3rd
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 3rd 3rd 1st
Q08211 ATP-dependent RNA helicase A 3rd 1st 1st
Q14683 Structural maintenance of chromosomes protein 1A 3rd 1st 1st
P04264 Keratin, type II cytoskeletal 1 3rd 1st 1st
Q9NYL9 Tropomodulin-3 3rd 3rd N/A
P21333 Filamin-A N/A 3rd 3rd
P55786 Puromycin-sensitive aminopeptidase N/A 2nd 1st
P52597 Heterogeneous nuclear ribonucleoprotein F N/A 1st 1st
Q04695 Keratin, type I cytoskeletal 17 N/A 2nd 2nd
P42330 Aldo-keto reductase family 1 member C3 N/A 1st 3rd
Q08J23 tRNA (cytosine-5-)-methyltransferase NSUN2 N/A 2nd N/A
P00966 Argininosuccinate synthase N/A 1st N/A
P10696 Alkaline phosphatase, placental-like N/A 1st N/A
  1. Note: 1st means that the protein was located as the 1st level neighbors of RKIP; 2nd means that the protein was located as the 2nd level neighbors of RKIP; 3rd means that the protein was located as the 3rd level neighbors of RKIP; and N/A means no interaction of RKIP with those proteins or the level of their interaction was > the 3rd level. *(bold font) means the validated proteins that interacted with RKIP.