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Table 2 The levels of interaction between the identified proteins and RKIP that located in the RKIP-interaction protein network diagrams (Figure 5 ), analyzed with the VisANT 3.8.6 protein-network analysis package

From: Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line

UniProt ID

Protein name

MiMI

Functional linage network

Predictome

P46940

Ras GTPase-activating-like protein IQGAP1

1st

1st

1st

P08238*

Heat shock protein HSP 90-beta

2 nd

1 st

1 st

Q14974

Importin subunit beta-1

1st

2nd

1st

P11142

Heat shock cognate 71 kDa protein

1st

1st

2nd

P14618

Pyruvate kinase isozymes M1/M2

1st

1st

1st

P06576

ATP synthase subunit alpha, mitochondrial

1st

1st

1st

P07437

Tubulin beta chain

1st

3rd

1st

P68104

Elongation factor 1-alpha 1

1st

1st

1st

P60709

Actin, cytoplasmic 1

1st

1st

2nd

P05783

Keratin, type I cytoskeletal 18

1st

2nd

2nd

Q15149

Plectin

1st

2nd

1st

P21796

Voltage-dependent anion-selective channel protein 1

1st

1st

1st

P23396

40S ribosomal protein S3

1st

2nd

1st

P63244

Guanine nucleotide-binding protein subunit beta-2-like 1

1st

2nd

2nd

Q00610

Clathrin heavy chain 1

1st

1st

1st

P41252

Isoleucyl-tRNA synthetase, cytoplasmic

1st

1st

1st

P60842

Eukaryotic initiation factor 4A-I

2nd

1st

1st

P04075

Fructose-bisphosphate aldolase A

2nd

1st

2nd

P52907

F-actin-capping protein subunit alpha-1

2nd

1st

1st

P04406

Glyceraldehyde-3-phosphate dehydrogenase

2nd

3rd

2nd

P07195

L-lactate dehydrogenase B chain

2nd

1st

2nd

P04083

Annexin A1

2nd

1st

2nd

P00338

L-lactate dehydrogenase A chain

2nd

1st

3rd

P62258*

14-3-3 protein epsilon

2 nd

1 st

1 st

P26640

Valyl-tRNA synthetase

2nd

1st

2nd

P08670

Vimentin

2nd

1st

2nd

P35579

Myosin-9

2nd

1st

1st

P18206

Vinculin

2nd

3rd

2nd

P13639

Elongation factor 2

2nd

1st

1st

P07900

Heat shock protein HSP 90-alpha

2nd

1st

1st

P38646

Stress-70 protein, mitochondrial

2nd

1st

2nd

P10809

60 kDa heat shock protein, mitochondrial

2nd

1st

1st

P05787*

Keratin, type II cytoskeletal 8

2 nd

2 nd

1 st

P06733

Alpha-enolase

2nd

3rd

1st

P26641

Elongation factor 1-gamma

2nd

2nd

1st

Q15029

small nuclear ribonucleoprotein component

3rd

1st

1st

P08195

4 F2 cell-surface antigen heavy chain

3rd

2nd

2nd

P53396

ATP-citrate synthase

3rd

1st

1st

O75369

Filamin-B

3rd

2nd

1st

P53992

Protein transport protein Sec24C

3rd

2nd

1st

P53618

Coatomer subunit beta

3rd

3rd

3rd

P14625

Endoplasmin

3rd

1st

1st

Q13263

Transcription intermediary factor 1-beta

3rd

2nd

1st

P02786

Transferrin receptor protein 1

3rd

3rd

1st

P55072

Transitional endoplasmic reticulum ATPase

3rd

1st

1st

O43390

Heterogeneous nuclear ribonucleoprotein R

3rd

2nd

3rd

P68371

Tubulin beta-2C chain

3rd

2nd

1st

P50454

Serpin H1

3rd

1st

1st

P00558

Phosphoglycerate kinase 1

3rd

1st

1st

P50395

Rab GDP dissociation inhibitor beta

3rd

1st

2nd

P40926

Malate dehydrogenase, mitochondrial

3rd

2nd

1st

Q99623

Prohibitin-2

3rd

2nd

3rd

P12429

Annexin A3

3rd

1st

3rd

P08758

Annexin A5

3rd

1st

3rd

O00299

Chloride intracellular channel protein 1

3rd

2nd

1st

P61289

Proteasome activator complex subunit 3

3rd

1st

1st

P09211

Glutathione S-transferase P

3rd

3rd

1st

Q06830

Peroxiredoxin-1

3rd

2nd

1st

P61026

Ras-related protein Rab-10

3rd

3rd

3rd

Q99714

3-hydroxyacyl-CoA dehydrogenase type-2

3rd

3rd

1st

Q08211

ATP-dependent RNA helicase A

3rd

1st

1st

Q14683

Structural maintenance of chromosomes protein 1A

3rd

1st

1st

P04264

Keratin, type II cytoskeletal 1

3rd

1st

1st

Q9NYL9

Tropomodulin-3

3rd

3rd

N/A

P21333

Filamin-A

N/A

3rd

3rd

P55786

Puromycin-sensitive aminopeptidase

N/A

2nd

1st

P52597

Heterogeneous nuclear ribonucleoprotein F

N/A

1st

1st

Q04695

Keratin, type I cytoskeletal 17

N/A

2nd

2nd

P42330

Aldo-keto reductase family 1 member C3

N/A

1st

3rd

Q08J23

tRNA (cytosine-5-)-methyltransferase NSUN2

N/A

2nd

N/A

P00966

Argininosuccinate synthase

N/A

1st

N/A

P10696

Alkaline phosphatase, placental-like

N/A

1st

N/A

  1. Note: 1st means that the protein was located as the 1st level neighbors of RKIP; 2nd means that the protein was located as the 2nd level neighbors of RKIP; 3rd means that the protein was located as the 3rd level neighbors of RKIP; and N/A means no interaction of RKIP with those proteins or the level of their interaction was > the 3rd level. *(bold font) means the validated proteins that interacted with RKIP.