From: Mapping the interactome of overexpressed RAF kinase inhibitor protein in a gastric cancer cell line
UniProt ID | Protein name | Protein mass (Da) | Score | Matching peptides | Protein function |
---|---|---|---|---|---|
I. Metabolic enzymes | |||||
P53618 | Coatomer subunit beta | 108,241 | 89 | 3 | Mediate biosynthetic protein transport |
P14618 | Pyruvate kinase isozymes M1/M2, isoform M2 | 58,470 | 604 | 40 | Glycolytic enzyme |
P00966 | Argininosuccinate synthase | 46,791 | 142 | 6 | ATP binding |
P00558 | Phosphoglycerate kinase 1 | 44,992 | 102 | 3 | Glycolytic enzyme |
P08195 | 4F2 cell-surface antigen heavy chain, isoform 2 | 68,180 | 56 | 2 | Function of light chain amino-acid transporters |
P06733 | Alpha-enolase | 47,481 | 517 | 25 | Multifunctional enzyme |
P04406 | Glyceraldehyde-3-phosphate dehydrogenase | 36,201 | 769 | 80 | Glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities |
P07195 | L-lactate dehydrogenase B chain | 36,900 | 74 | 5 | L-lactate dehydrogenase activity |
P00338 | L-lactate dehydrogenase A chain, isoform 1 | 36,950 | 43 | 4 | L-lactate dehydrogenase activity |
P40926 | Malate dehydrogenase, mitochondrial | 35,937 | 49 | 3 | L-malate dehydrogenase activity |
P46940 | Ras GTPase-activating-like protein IQGAP1 | 189,761 | 55 | 3 | Promote neurite outgrowth |
P68104 | Elongation factor 1-alpha 1 | 50,451 | 190 | 11 | Protein biosynthesis |
P02786 | Transferrin receptor protein 1 | 85,274 | 74 | 3 | Molecular transducer activity |
II. Molecular chaperone | |||||
P14625 | Endoplasmin | 92,696 | 192 | 18 | Molecular chaperone ATPase activity |
P07900 | Heat shock protein HSP 90-alpha, isoform 2 | 85,006 | 280 | 24 | Stress related, chaperone |
P08238 | Heat shock protein HSP 90-beta | 83,554 | 276 | 25 | Stress related, chaperone |
P11142 | Heat shock cognate 71Â kDa protein, isoform 1 | 71,082 | 398 | 16 | Stress related, chaperone |
P38646 | Stress-70 protein, mitochondrial | 73,920 | 253 | 7 | Related with cellular proliferation and aging |
P10809 | 60Â kDa heat shock protein, mitochondrial | 61,187 | 723 | 22 | Stress related, chaperone |
P53992 | Protein transport protein Sec24C | 119,789 | 61 | 5 | Component of the COPII coat |
P50454 | Serpin H1 | 46,525 | 133 | 3 | Chaperone in the biosynthetic pathway of collagen |
III. Biological oxidation-related proteins | |||||
O00299 | Chloride intracellular channel protein 1 | 27,248 | 78 | 3 | Voltage-gated chloride channel activity, redox-regulated |
Q06830 | Peroxiredoxin-1 | 22,324 | 51 | 7 | Redox regulation |
IV. Signal transduction | |||||
O43390 | Heterogeneous nuclear ribonucleoprotein R, isoform 1 | 71,184 | 63 | 2 | mRNA processing, ribonucleoprotein |
P52597 | Heterogeneous nuclear ribonucleoprotein F | 45,985 | 110 | 2 | mRNA processing, ribonucleoprotein |
P04083 | Annexin A1 | 38,918 | 454 | 24 | Signal transduction, calcium ion binding |
P12429 | Annexin A3 | 36,524 | 53 | 4 | Signal transduction, calcium ion binding |
P08758 | Annexin A5 | 35,971 | 50 | 10 | Signal transduction, calcium ion binding |
P62258 | 14-3-3 protein epsilon | 29,326 | 136 | 6 | Anti-apoptosis, signal transduction, transcription factor binding |
P23396 | 40S ribosomal protein S3 | 26,842 | 122 | 9 | NF-KappaB binding |
Q99623 | Prohibitin-2 | 33,276 | 38 | 5 | Mediate transcriptional repression |
V. Cytoskeleton-related proteins | |||||
O75369 | Filamin-B, isoform 1 | 280,157 | 91 | 1 | Connects cell membrane constituents to the actin cytoskeleton |
P21333 | Filamin-A, isoform 2 | 283,301 | 91 | 3 | Actin binding |
P18206 | Vinculin, isoform 1 | 124,292 | 668 | 30 | Actin filament-binding protein |
P04264 | Keratin, type II cytoskeletal 1 | 66,170 | 89 | 4 | Cytoskeleton of Intermediate filaments |
P05787 | Keratin, type II cytoskeletal 8 | 53,671 | 156 | 11 | Cytoskeleton of Intermediate filaments |
Q04695 | Keratin, type I cytoskeletal 17 | 48,361 | 221 | 10 | Cytoskeleton of Intermediate filaments |
P05783 | Keratin, type I cytoskeletal 18 | 48,029 | 547 | 35 | Cytoskeleton of Intermediate filaments |
Q15149 | Plectin-1, isoform 1 | 533,462 | 73 | 11 | Actin binding |
P35579 | Myosin-9, isoform 1 | 227,646 | 62 | 10 | Play a role in cytokinesis, secretion |
P68371 | Tubulin beta-2C chain | 50,255 | 245 | 19 | The major constituent of microtubules |
P07437 | Tubulin beta chain | 50,095 | 309 | 25 | The major constituent of microtubules |
P60709 | Actin, cytoplasmic 1 | 42,058 | 617 | 36 | Involved in various types of cell motility |
P52907 | F-actin-capping protein subunit alpha-1 | 33,073 | 61 | 3 | Actin binding |
P04075 | Fructose-bisphosphate aldolase A | 39,851 | 141 | 7 | Actin binding |
P08670 | Vimentin | 53,619 | 574 | 17 | Cell motility, structural constituent of cytoskeleton |
Q9NYL9 | Tropomodulin-3 | 39,741 | 85 | 9 | Actin binding |
VI. Protease-related proteins | |||||
P53396 | ATP-citrate synthase | 121,674 | 225 | 7 | Enzyme regulator activity |
P55072 | Transitional endoplasmic reticulum ATPase | 89,950 | 42 | 3 | Necessary for the formation of transitional endoplasmic reticulum |
Q08J23 | tRNA (cytosine-5-)-methyl transferase NSUN2 | 87,214 | 78 | 2 | RNA methyltransferase |
P06576 | ATP synthase subunit alpha, mitochondrial | 59,828 | 158 | 9 | Mitochondrial membrane ATP synthase |
P60842 | Eukaryotic initiation factor 4A-I | 46,357 | 169 | 7 | ATP-dependent RNA helicase |
P55786 | Puromycin-sensitive aminopeptidase | 103,895 | 117 | 3 | Involved in proteolytic events essential for cell growth and viability |
P50395 | Rab GDP dissociation inhibitor beta | 51,095 | 78 | 3 | Rad GDP-dissociation inhibitor activity |
P42330 | Aldo-keto reductase family 1 member C3 | 37,229 | 35 | 2 | Aldo-keto reductase activity |
P63244 | Guanine nucleotide-binding protein subunit beta-2-like 1 | 35,511 | 112 | 3 | Up-regulation of the activity of kinases |
P61289 | Proteasome activator complex subunit 3, isoform 1 | 29,602 | 77 | 2 | Endopeptidase activator activity |
P09211 | Glutathione S-transferase P | 23,569 | 56 | 30 | Glutathione transferase activity |
P13639 | Elongation factor 2 | 96,246 | 240 | 9 | Catalyzes the GTP-dependent ribosomal translocation |
Q15029 | 116Â kDa U5 small nuclear ribonucleoprotein component | 110,336 | 130 | 6 | Component of the U5 snRNP complex |
P10696 | Alkaline phosphatase, placental-like | 57,626 | 140 | 8 | Alkaline phosphatase activity |
Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2, isoform 1 | 27,134 | 108 | 3 | Mitochondrial tRNA maturation |
Q08211 | ATP-dependent RNA helicase A | 142,181 | 264 | 12 | Transcriptional activator |
P41252 | Isoleucyl-tRNA synthetase, cytoplasmic | 145,718 | 94 | 9 | Isoleucine-tRNA ligase activity |
P26640 | Valyl-tRNA synthetase | 141,642 | 78 | 4 | ATP binding |
VII. Others | |||||
Q13263 | Transcription intermediary factor 1-beta, isoform 1 | 90,261 | 59 | 3 | Nuclear corepressor for KRAB domain-containing zinc finger proteins |
Q14974 | Importin subunit beta-1 | 98,420 | 84 | 2 | Protein domain specific binding |
P26641 | Elongation factor 1-gamma | 50,429 | 65 | 2 | Unknown |
P21796 | Voltage-dependent anion-selective channel protein 1 | 30,868 | 78 | 3 | Voltage-gated anion channel activity |
P61026 | Ras-related protein Rab-1A, isoform 1 | 22,755 | 45 | 1 | Involved in vesicular trafficking and neurotransmitter release. |
Q00610 | Clathrin heavy chain 1, isoform 1 | 193,620 | 36 | 3 | The polyhedral coat of coated pits and vesicles |
Q14683 | Structural maintenance of chromosomes protein 1A | 143,771 | 221 | 6 | Involved in chromosome cohesion |