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Table 3 Rates of HBV screening a by screening period

From: Trends in hepatitis B virus screening at the onset of chemotherapy in a large US cancer center

Characteristic Period 1b Period 2c Period 3d P valuee
All patients Screened patients All patients Screened patients All patients Screened patients
  (N = 11,833) (N = 1754) (N = 5703) (N = 1037) (N = 1152) (N = 229)
Age, years, mean (SD) 54.8 (13.6) 51.6 (15.6) 55.1 (13.4) 53.1 (15.2) 56.4 (13.1) 56.1 (14.7) 0.0001
Sex, no. (%)        
 Female 6702 731 (10.9) 3263 464 (14.2) 14.22 643 110 (17.1) 17.11 <0.0001
 Male 5131 1023 (20.0) 19.94 2440 573 (23.5) 23.48 509 119 (23.4) 23.38 0.0003
Race/ethnicity, no. (%)        
 White 8464 1269 (15.0) 3895 738 (19.0) 809 161 (19.9) <0.0001
 Hispanic 1441 218 (15.1) 747 152 (20.4) 131 32 (24.0) <0.0001
 Black 1301 143 (11.0) 654 83 (12.7) 137 21 (15.3) 0.04
 Asian 311 45 (14.5) 158 23 (14.6) 39 8 (19.4) 0.23
 Other 316 79 (25.0) 249 41(16.5) 36 7 (20.5) 0.02
US residence, no. (%) 11,480 1675 (14.6) 5499 997 (18.1) 1111 224 (20.0) <0.0001
HBV risk factor, no. (%) 3412 572 (16.8) 1668 356 (21.3) 311 88 (28.3) <0.0001
Cancer type, no. (%)        <0.0001
 Solid tumorf 9521 326 (3.4) 4602 208 (4.5) 908 47 (5.2) <0.0001
 Hematologic malignancy 2312 1428 (61.8) 1101 829 (75.3) 244 182 (74.6) <0.0001
Chemotherapy        
Type, n (%)
 Rituximab 1244 785 (63.1) 606 481 (79.4) 127 94 (74.0) <0.0001
 Non-rituximab 10,589 969 (9.4) 5097 556 (10.9) 1025 135 (13.2) <0.0001
  1. Abbreviations: HBV hepatitis B virus, SD standard deviation, US United States.
  2. aHBV screening means that both hepatitis B surface antigen (HBsAg) test and antibody to hepatitis B core antigen (anti-HBc) test were ordered.
  3. bFirst chemotherapy administration from 1/1/04 through 12/18/2008.
  4. cFirst chemotherapy administration from 12/19/2008 through 9/30/2010.
  5. dFirst chemotherapy administration from 10/1/2010 through 4/30/11.
  6. eCochran-Armitage trend test compares screened patients vs. unscreened patients, over the 3 time periods.
  7. fExcludes primary liver cancer.