Skip to main content

Table 2 Expression of progastrin, p-ERK1/2 and pY-STAT3 in hyperplastic polyps

From: Activation of pro-oncogenic pathways in colorectal hyperplastic polyps

Variables Total Progastrin staining in HP epithelial cells  
  N = 48 No/Low expression Moderate expression High expression p-value
   N = 21 N = 12 N = 15  
Percentage of p-ERK1/2 stained cells, N mean (SD) N = 43 33% (30) N = 18 27% (29) N = 12 23% (22) N = 13 53% (29) 0.015a
Expression of p-ERK1/2      0.008b
No/low expression 35% [21%-51%] 50% [26%-74%] 42% [15%-72%] 8% [0%-36%]  
Moderate expression 37% [23%-53%] 33% [13%-59%] 42% [15%-72%] 38% [14%-68%]  
High expression 28% [15%-44%] 17% [4%-41%] 16% [2%-48%] 54% [25%-81%]  
Percentage of pY-STAT3 stained cells, N mean (SD) N = 35 10% (23) N = 15 11% (29) N = 7 3% (7) N = 13 12% (23) 0.297
Expression of pY-STAT3      0.3116
No/low expression 77% [60%-90%] 80% [52%-96%] 86% [42%-100%] 69% [39%-91%]  
Moderate expression 14% [5%-30%] 7% [0%-32%] 14% [0%-58%] 23% [5%-54%]  
High expression 9% [2%-23%] 13% [2%-40%] 0% [0%-41%] 8% [0%-36%]  
  1. SD: standard deviation.
  2. (a)Cuzick test for trend across ordered groups.
  3. (b)Spearman nonparametric correlation test was used for comparison of ordered qualitative variable.
  4. Expressions of PG, .P-ERK and PY-STAT3 were analyzed as a 3 classes variable: no/low expression, moderate expression and high expression as detailed in “Methods”.