Activation of pro-oncogenic pathways in colorectal hyperplastic polyps

BMC Cancer

Table 2 Expression of progastrin, p-ERK1/2 and pY-STAT3 in hyperplastic polyps

Variables	Total	Progastrin staining in HP epithelial cells
	N = 48	No/Low expression	Moderate expression	High expression	p-value
		N = 21	N = 12	N = 15
Percentage of p-ERK1/2 stained cells, N mean (SD)	N = 43 33% (30)	N = 18 27% (29)	N = 12 23% (22)	N = 13 53% (29)	0.015_a
Expression of p-ERK1/2					0.008_b
No/low expression	35% [21%-51%]	50% [26%-74%]	42% [15%-72%]	8% [0%-36%]
Moderate expression	37% [23%-53%]	33% [13%-59%]	42% [15%-72%]	38% [14%-68%]
High expression	28% [15%-44%]	17% [4%-41%]	16% [2%-48%]	54% [25%-81%]
Percentage of pY-STAT3 stained cells, N mean (SD)	N = 35 10% (23)	N = 15 11% (29)	N = 7 3% (7)	N = 13 12% (23)	0.297
Expression of pY-STAT3					0.3116
No/low expression	77% [60%-90%]	80% [52%-96%]	86% [42%-100%]	69% [39%-91%]
Moderate expression	14% [5%-30%]	7% [0%-32%]	14% [0%-58%]	23% [5%-54%]
High expression	9% [2%-23%]	13% [2%-40%]	0% [0%-41%]	8% [0%-36%]

SD: standard deviation.
(a)Cuzick test for trend across ordered groups.
(b)Spearman nonparametric correlation test was used for comparison of ordered qualitative variable.
Expressions of PG, .P-ERK and PY-STAT3 were analyzed as a 3 classes variable: no/low expression, moderate expression and high expression as detailed in “Methods”.

ISSN: 1471-2407