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Table 1 Clinical and histological features of hyperplastic polyps

From: Activation of pro-oncogenic pathways in colorectal hyperplastic polyps

Variables Total of HP Progastrin staining in HP epithelial cells  
  N = 48 No/Low expression Moderate expression High expression p-value
   N = 21 N = 12 N = 15  
Age, mean (SD) 65 y.o.(12) 61 y.o.(14) 68 y.o (10) 68 y.o (8) 0.2613
Median [min-max] 66 y.o. [30–89] 65 y.o. [30–80] 70 y.o. [51–89] 66 y.o. [53–79]  
Sex, % (95% CI)      0.019
Female 44% [29%-59%] 33% [15%-57%] 25% [5%-57%] 73% [45%-92%]  
Male 56% [41%-71%] 67% [43%-85%] 75% [43%-95%] 27% [8%-55%]  
History of adenoma or adenocarcinoma, % (95% CI) 29% [17%-44%] 33% [15%-57%] 42% [15%-72%] 13% [2%-40%] 0.280a
Synchronous Adenoma or adenocarcinoma, % (95% CI) 48% [33%-63%] 48% [26%-70%] 33% [10%-65%] 60% [32%-84%] 0.387
Localisation, % (95% CI)      0.154a
Proximal colon 27% [15%-42%] 19% [5%-42%] 17% [2%-48%] 47% [21%-73%]  
Distal colon 73% [58%-85%] 81% [58%-95%] 83% [52%-98%] 53% [27%-79%]  
HP histologic features      0.784a
Goblet-cell rich HP 83% [70%-93%] 81% [58%-95%] 92% [62%-100%] 80% [52%-96%]  
Microvesicular HP 17% [7%-30%] 19% [5%-42%] 8% [0%-38%] 20% [4%-48%]  
  1. Progastrin expression was analyzed as a 3 classes variable: no/low expression, moderate expression and high expression as detailed in “Methods”. Chi 2 tests (for categorical variables) and Kruskal-Wallis test (for continuous variables) were performed to compare clinical and immune-histological features between progastrin expression groups. 95% CI: Binomial exact 95- confidence interval was calculated for each percentage, if no other mention. SD: standard deviation a: Fischer exact test.