Table 1 Clinical and histological features of hyperplastic polyps
From: Activation of pro-oncogenic pathways in colorectal hyperplastic polyps
Variables | Total of HP | Progastrin staining in HP epithelial cells | |||
|---|---|---|---|---|---|
N = 48 | No/Low expression | Moderate expression | High expression | p-value | |
N = 21 | N = 12 | N = 15 | |||
Age, mean (SD) | 65 y.o.(12) | 61 y.o.(14) | 68 y.o (10) | 68 y.o (8) | 0.2613 |
Median [min-max] | 66 y.o. [30–89] | 65 y.o. [30–80] | 70 y.o. [51–89] | 66 y.o. [53–79] | |
Sex, % (95% CI) | 0.019 | ||||
Female | 44% [29%-59%] | 33% [15%-57%] | 25% [5%-57%] | 73% [45%-92%] | |
Male | 56% [41%-71%] | 67% [43%-85%] | 75% [43%-95%] | 27% [8%-55%] | |
History of adenoma or adenocarcinoma, % (95% CI) | 29% [17%-44%] | 33% [15%-57%] | 42% [15%-72%] | 13% [2%-40%] | 0.280a |
Synchronous Adenoma or adenocarcinoma, % (95% CI) | 48% [33%-63%] | 48% [26%-70%] | 33% [10%-65%] | 60% [32%-84%] | 0.387 |
Localisation, % (95% CI) | 0.154a | ||||
Proximal colon | 27% [15%-42%] | 19% [5%-42%] | 17% [2%-48%] | 47% [21%-73%] | |
Distal colon | 73% [58%-85%] | 81% [58%-95%] | 83% [52%-98%] | 53% [27%-79%] | |
HP histologic features | 0.784a | ||||
Goblet-cell rich HP | 83% [70%-93%] | 81% [58%-95%] | 92% [62%-100%] | 80% [52%-96%] | |
Microvesicular HP | 17% [7%-30%] | 19% [5%-42%] | 8% [0%-38%] | 20% [4%-48%] | |