TP53 mutated colorectal carcinoma xenografts are resistant to PPP treatment. (A). The TP53 mutated CACO-2 cells were injected subcutaneously in mice and once the subcutaneous xenografts were formed, the mice were treated either with PPP (50 mg/kg) or saline through oral gavage, twice per week. The tumor volumes from the same group of mice were grouped and presented as mean ± SD. **, p < 0.01. (B). The mice bearing xenografts were shown at necropsy with a saline-treated mouse on the left and a PPP-treated mouse on the right. (C). The xenograft tumors (T) from saline treated (−) and PPP treated mice (+) were examined by western blotting for the presence of the phosphorylated and unphosphorylated IGF-1R, AKT and ERK.