Skip to main content
Figure 4 | BMC Cancer

Figure 4

From: The association of TP53 mutations with the resistance of colorectal carcinoma to the insulin-like growth factor-1 receptor inhibitor picropodophyllin

Figure 4

PPP resistance is in part due to the inhibition of BAD-mediated mitochondrial pathway. (A). The TP53 wild type HCT-8 and mutated CACO-2 were treated with 500 nM PPP for the indicated hours and then subjected to western blotting for the presence of the phosphorylated and unphosphorylated BAD and cleavage of XIAP protein. (B). The PPP treated cells were further examined by western blotting for the cleavage of caspase-9, caspase-3, PARP and DFF45 in HCT-8 and CACO-2 cells with the proteins and cleavage products indicated to the right side of the panel.

Back to article page