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Table 2 Univariate Cox proportional hazards regression analysis for overall survival and relapse-free survival

From: Expression of nerve growth factor and heme oxygenase-1 predict poor survival of breast carcinoma patients

Characteristics

No.

OS

  

RFS

  
  

HR

95% CI

P

HR

95% CI

P

Age, y, ≥ 50 (vs. < 50)

41/145

2.928

1.620-5.293

< 0.001

1.914

1.112-3.295

0.019

TNM stage, I

29/145

1

 

0.016

1

 

0.197

        II

97/145

2.482

0.874-7.046

0.088

1.386

0.644-2.983

0.403

      III and IV

19/145

5.154

1.614-16.457

0.006

2.288

0.902-5.799

0.081

Histologic grade, 1

49/145

1

 

0.014

1

 

0.087

        2

67/145

1.218

0.575-2.579

0.607

1.147

0.598-2.198

0.680

        3

29/145

2.818

1.293-6.139

0.009

2.077

1.027-4.203

0.042

HER2, positive (vs. negative)

40/145

2.765

1.525-5.012

< 0.001

2.596

1.511-4.461

< 0.001

ER, positive (vs. negative)

80/145

0.691

0.382-1.250

0.222

0.911

0.533-1.557

0.733

NGF, positive (vs. negative)

45/145

4.674

2.541-8.598

< 0.001

3.55

2.074-6.076

< 0.001

HO1, positive (vs. negative)

71/145

6.101

2.832-13.143

< 0.001

3.476

1.914-6.314

< 0.001

NGF/HO1, NGF-/HO1-

69/145

1

 

< 0.001

1

 

< 0.001

      NGF-/HO1+

31/145

5.019

1.855-13.578

0.001

2.935

1.338-6.436

0.007

      NGF+/anyHO1

45/145

9.717

4.003-23.586

< 0.001

5.41

2.754-10.625

< 0.001

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BMC Cancer

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