Tumor tissue | ANOVA | ||||||
---|---|---|---|---|---|---|---|
Mucosa | Stadium I | Stadium II | Stadium III | Stadium IV | Tumor vs mucosa p value | Stage I-IV p value | |
RNA (n) | (26) | (5) | (8) | (10) | (4) | ||
COX-1 | 10.45 ± 1.59 | 2.82 ± 0.90 | 3.40 ± 0.71 | 1.57 ± 0.34 | 7.04 ± 2.42 | <0.0001 | ns |
COX-2 | 0.50 ± 0.21 | 0.27 ± 0.13 | 0.81 ± 0.21 | 1.02 ± 0.39 | 1.58 ± 0.68 | ns | ns |
EGFR | 13.66 ± 1.26 | 4.90 ± 1.40 | 5.28 ± 0.89 | 3.37 ± 0.58 | 7.02 ± 0.83 | <0.0001 | ns |
Protein (n) | (30) | (5) | (10) | (10) | (5) | ||
COX-1 | 2.43 ± 0.19 | 1.97 ± 0.50 | 1.92 ± 0.38 | 2.98 ± 0.61 | 1.97 ± 0.50 | ns | ns |
COX-2 total* | 1.24 ± 0.10 | 1.53 ± 0.36 | 3.57 ± 0.68 | 2.34 ± 0.26 | 3.42 ± 0.70 | <0.0001 | I,II 0.002 |
I,IV 0.009 | |||||||
COX-2 66 kDa | 1.00 ± 0.13 | 1.25 ± 0.33 | 1.63 ± 0.51 | 1.59 ± 0.32 | 1.62 ± 0.22 | 0.028 | ns |
COX-2 74 kDa | 0.20 ± 0.02 | 0.25 ± 0.09 | 1.70 ± 0.68 | 0.70 ± 0.22 | 1.49 ± 0.82 | 0.003 | I,II 0.014 |
II,III 0.036 | |||||||
EGFR extra | 0.64 ± 0.06 | 0.91 ± 0.09 | 0.43 ± 0.12 | 0.40 ± 0.10 | 0.44 ± 0.15 | ns | I,II 0.009 |
I,III 0.006 | |||||||
I,IV 0.023 | |||||||
EGFR intra | 0.54 ± 0.09 | 0.40 ± 0.19 | 0.14 ± 0.06 | 0.54 ± 0.16 | 0.42 ± 0.15 | ns | ns |