Common low-penetrance risk variants associated with breast cancer in Polish women

BMC Cancer

Table 3 SNPs selected for analysis

NCBI SNP Reference	Cytogenetic Band	Gene^a	Reference
rs17468277	2q33.1	ALS2CR12 (synonymous) (CASP8)^b	[35]
rs13387042	2q35	intergenic	[32, 33]
rs889312	5q11.2	MAP3K1 (upstream)	[8, 33]
rs10941679	5p12	intergenic	[8, 34]
rs2736098	5p15.33	TERT (synonymous)	[31]
rs13281615	8q24.21	intergenic	[8, 33]
rs3731249	9p21.3	CDKN2A (missense; A148T)	[37], CO-I^c
rs1219648	10q26	FGFR2 (intron)	[30]
rs2981582	10q26	FGFR2 (intron)	[8, 33]
rs3817198	11p15.5	LSP1 (intron)	[8]
rs766173	13q13.1	BRCA2 (missense; N289H)	CO-I
rs1799944	13q13.1	BRCA2 (missense; N991D)	[36], CO-I
rs28897710	13q13.1	BRCA2 (missense; T598A)	CO-I
rs3803662	16q12.1	TOX3/LOC643714 (between)	[8, 32, 33]
rs243865	16q13-q21	MMP2 (promoter)	[29]
rs152451	16p12.2	PALB2 (missense; Q559R)	CO-I

^a/NCBI ID of genes localized in proximity to the SNPs of interest (source: HapMap).
^b/SNP rs17468277 is in strong LD (r ² = 1) with rs1045485 in CASP8 (D302H).
^c/SNP selected based on the date provided by Genetic Counseling of Cancer Center and Institute of Oncology (CO-I) in Warsaw.

ISSN: 1471-2407