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Table 1 Down-regulated genes located on 4q35 and 10p14-15

From: SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes

Agilent-Nr

Gene

Symbol

Chromosome

Expression Array

Real-time PCR

Ratio CIN3/CxCa (p-value)

A_23_P104413

double homeobox, 4

DUX4

4q35

-1.92 (0.0382)

n.d.

A_23_P121795

sorbin and SH3 domain containing 2

SORBS2

4q35.1

-1.83 (0.0487)

-31.709 (<0.001)

A_23_P140884

tubulin, beta polypeptide 4, member Q

TUBB4Q

4q35

-1.76 (0.0409)

n.d.

A_23_P29922

toll-like receptor 3

TLR3

4q35

-2.3 (0.0024)

-6.437 (<0.001)

A_23_P358470

coiled-coil domain containing 111

CCDC111

4q35.1

-1.56 (0,0213)

n.d.

A_23_P58180

cytochrome P450, family 4, subfamily V, polypeptide 2

CYP4V2

4q35.2

-1.96 (0.0446)

-6.144 (<0.001)

A_23_P104252

inter-alpha (globulin) inhibitor H5

ITIH5

10p14

-4.14 (0.0301)

n.d.

A_23_P12849

F-box protein, helicase, 18

FBXO18

10p15.1

-1.34 (0.0228)

-2.445 (<0.001)

A_23_P1374

protein kinase C, theta

PRKCQ

10p15

-3.69 (0.0428)

-8.048 (<0.001)

A_23_P138680

Interleukin 15 receptor, alpha

IL15RA

10p15-p14

-1.68 (0.00312)

-2.973 (<0.001)

A_23_P47073

WD repeat domain 37

WDR37

10p15.3

-1.39 (0.0355)

-4.676 (<0.001)

A_23_P75056

GATA binding protein 3

GATA3

10p15

-1.5 (0.0222)

-30.061 (<0.001)

A_24_P111096

6-phospho-fructo-2-kinase /fructose-2,6-bisphosphatase

PFKFB3

10p14-p15

-1.69 (0.017)

-1.971 (0.0174)

A_24_P242705

tRNA aspartic acid methyl-transferase 1

TRDMT1

10p15.1

-1.55 (0.0238)

n.d.

A_24_P360722

DIP2 disco-interacting protein 2 homolog C (Drosophila)

DIP2C

10p15.3

-1.39 (0.0433)

-3.368 (<0.001)

  1. n.d. – not determined.