Figure 3From: SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes Endogenous expression of SORBS2 and p16 INK4A during in vitro passaging of primary keratinocytes. Immunocytochemical staining of endogenously expressed SORBS2 and p16INK4A in primary human keratinocytes of the donor FK09-9 (A) at passage 5 and (B) at passage 7 was performed. Strong endogenous expression of p16INK4a and SORBS2 correlated with a near senescent stage of the cells (B). (a, c magnification ×100; b, d magnification ×200)Back to article page