|
Variable
|
Total
|
CD34 Chalkley count
|
HIF-1α
|
VEGF
|
|---|
| |
N
|
Low
|
High (%)
|
P value
|
Low
|
High (%)
|
P value
|
Low
|
High (%)
|
P value
|
|---|
|
Age
| | | |
0.251
| | |
0.281
| | |
0.681
|
|
25–69
|
59
|
30
|
29 (49)
| |
34
|
25 (42)
| |
36
|
23 (39)
| |
|
70–84
|
81
|
29
|
52 (64)
| |
55
|
26 (32)
| |
46
|
35 (43)
| |
|
85+
|
18
|
8
|
10 (56)
| |
12
|
6 (33)
| |
13
|
5 (28)
| |
|
FIGO
| | | |
0.672
| | |
0.222
| | |
0.082
|
|
Ia
|
0
|
0
|
0 (0)
| |
0
|
0 (0)
| |
0
|
0 (0)
| |
|
Ib
|
77
|
35
|
42 (55)
| |
51
|
26 (34)
| |
48
|
29 (38)
| |
|
II
|
7
|
2
|
5 (71)
| |
4
|
3 (43)
| |
7
|
0 (0)
| |
|
IIIa
|
30
|
14
|
16 (53)
| |
13
|
17 (57)
| |
20
|
10 (33)
| |
|
IIIb
|
26
|
8
|
18 (69)
| |
18
|
8 (31)
| |
11
|
15 (58)
| |
|
IIIc
|
7
|
2
|
5 (71)
| |
5
|
2 (29)
| |
4
|
3 (43)
| |
|
IVa
|
1
|
1
|
0 (0)
| |
1
|
0 (0)
| |
0
|
1 (100)
| |
|
IVb
|
7
|
3
|
4 (57)
| |
6
|
1 (14)
| |
4
|
3 (43)
| |
|
Not available
|
3
| | | | | | | | | |
|
Lymph node metastasis
| | | |
0.213
| | |
0.543
| | |
0.113
|
|
None
|
87
|
39
|
48 (55)
| |
58
|
29 (33)
| |
55
|
31 (37)
| |
|
Unilateral
|
44
|
19
|
25 (57)
| |
25
|
19 (43)
| |
29
|
15 (34)
| |
|
Bilateral
|
24
|
6
|
18 (75)
| |
15
|
9 (38)
| |
10
|
14 (58)
| |
|
Not available
|
3
| | | | | | | | | |
|
Tumor diameter (cm)
| | | |
0.0021
| | |
0.951
| | |
0.981
|
|
0.3–2.5
|
32
|
19
|
13 (41)
| |
19
|
13 (41)
| |
20
|
12 (38)
| |
|
2.6–4.0
|
51
|
24
|
27 (53)
| |
33
|
16 (31)
| |
30
|
21 (41)
| |
|
4.1–20.0
|
72
|
21
|
51 (71)
| |
44
|
28 (39)
| |
44
|
28 (39)
| |
|
Not available
|
3
| | | | | | | | | |
|
Tumor differentiation
| | | |
0.073
| | |
0.233
| | |
0.0073
|
|
Well
|
35
|
19
|
16 (46)
| |
26
|
9 (26)
| |
19
|
16 (46)
| |
|
Moderate
|
92
|
32
|
60 (65)
| |
54
|
38 (41)
| |
64
|
28 (30)
| |
|
Poor
|
31
|
16
|
15 (48)
| |
21
|
10 (32)
| |
12
|
19 (61)
| |
|
Depth of invasion (mm)
| | | |
<0.0011
| | |
0.581
| | |
0.781
|
|
0.0–4.0
|
26
|
19
|
7 (27)
| |
17
|
9 (35)
| |
15
|
11 (42)
| |
|
4.1–8.0
|
56
|
26
|
30 (54)
| |
37
|
19 (34)
| |
37
|
19 (34)
| |
|
8.1–40.0
|
74
|
20
|
54 (73)
| |
45
|
29 (39)
| |
43
|
31 (42)
| |
|
Not available
|
2
| | | | | | | | | |
|
Infiltration of vessel
| | | |
0.553
| | |
0.063
| | |
0.733
|
|
No
|
116
|
51
|
65 (56)
| |
70
|
46 (40)
| |
72
|
44 (38)
| |
|
Yes
|
39
|
15
|
24 (62)
| |
30
|
9 (23)
| |
23
|
16 (41)
| |
|
Not available
|
3
| | | | | | | | | |
-
1Linear-by-linear association.
-
2Fisher’s exact test.
-
3Pearson chi-square.
- Low: CD34 Chalkley count < 8; High: CD34 Chalkley count ≥ 8.
- Low: HIF-1α in ≤ 50% tumor cells; High: HIF-1α in > 50% tumor cells.
- Low: VEGF score < 6, High: VEGF score ≥ 6.
