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Table 1 CD34 Chalkley count, HIF-1α and VEGF expression in relation to clinicopathological variables in vulvar carcinomas

From: Primary Tumor Vascularity, HIF-1α and VEGF expression in vulvar squamous cell carcinomas: their relationships with clinicopathological characteristics and prognostic impact

Variable Total CD34 Chalkley count HIF-1α VEGF
  N Low High (%) P value Low High (%) P value Low High (%) P value
Age     0.251    0.281    0.681
 25–69 59 30 29 (49)   34 25 (42)   36 23 (39)  
 70–84 81 29 52 (64)   55 26 (32)   46 35 (43)  
 85+ 18 8 10 (56)   12 6 (33)   13 5 (28)  
FIGO     0.672    0.222    0.082
 Ia 0 0 0 (0)   0 0 (0)   0 0 (0)  
 Ib 77 35 42 (55)   51 26 (34)   48 29 (38)  
 II 7 2 5 (71)   4 3 (43)   7 0 (0)  
 IIIa 30 14 16 (53)   13 17 (57)   20 10 (33)  
 IIIb 26 8 18 (69)   18 8 (31)   11 15 (58)  
 IIIc 7 2 5 (71)   5 2 (29)   4 3 (43)  
 IVa 1 1 0 (0)   1 0 (0)   0 1 (100)  
 IVb 7 3 4 (57)   6 1 (14)   4 3 (43)  
 Not available 3          
Lymph node metastasis     0.213    0.543    0.113
 None 87 39 48 (55)   58 29 (33)   55 31 (37)  
 Unilateral 44 19 25 (57)   25 19 (43)   29 15 (34)  
 Bilateral 24 6 18 (75)   15 9 (38)   10 14 (58)  
 Not available 3          
Tumor diameter (cm)     0.0021    0.951    0.981
 0.3–2.5 32 19 13 (41)   19 13 (41)   20 12 (38)  
 2.6–4.0 51 24 27 (53)   33 16 (31)   30 21 (41)  
 4.1–20.0 72 21 51 (71)   44 28 (39)   44 28 (39)  
 Not available 3          
Tumor differentiation     0.073    0.233    0.0073
 Well 35 19 16 (46)   26 9 (26)   19 16 (46)  
 Moderate 92 32 60 (65)   54 38 (41)   64 28 (30)  
 Poor 31 16 15 (48)   21 10 (32)   12 19 (61)  
Depth of invasion (mm)     <0.0011    0.581    0.781
 0.0–4.0 26 19 7 (27)   17 9 (35)   15 11 (42)  
 4.1–8.0 56 26 30 (54)   37 19 (34)   37 19 (34)  
 8.1–40.0 74 20 54 (73)   45 29 (39)   43 31 (42)  
 Not available 2          
Infiltration of vessel     0.553    0.063    0.733
 No 116 51 65 (56)   70 46 (40)   72 44 (38)  
 Yes 39 15 24 (62)   30 9 (23)   23 16 (41)  
 Not available 3          
  1. 1Linear-by-linear association.
  2. 2Fisher’s exact test.
  3. 3Pearson chi-square.
  4. Low: CD34 Chalkley count < 8; High: CD34 Chalkley count ≥ 8.
  5. Low: HIF-1α in ≤ 50% tumor cells; High: HIF-1α in > 50% tumor cells.
  6. Low: VEGF score < 6, High: VEGF score ≥ 6.