Table 1 CD34 Chalkley count, HIF-1α and VEGF expression in relation to clinicopathological variables in vulvar carcinomas

Age

0.25¹

0.28¹

0.68¹

 25–69

59

30

29 (49)

34

25 (42)

36

23 (39)

 70–84

81

29

52 (64)

55

26 (32)

46

35 (43)

 85+

18

8

10 (56)

12

6 (33)

13

5 (28)

FIGO

0.67²

0.22²

0.08²

 Ia

0

0

0 (0)

0

0 (0)

0

0 (0)

 Ib

77

35

42 (55)

51

26 (34)

48

29 (38)

 II

7

2

5 (71)

4

3 (43)

7

0 (0)

 IIIa

30

14

16 (53)

13

17 (57)

20

10 (33)

 IIIb

26

8

18 (69)

18

8 (31)

11

15 (58)

 IIIc

7

2

5 (71)

5

2 (29)

4

3 (43)

 IVa

1

1

0 (0)

1

0 (0)

0

1 (100)

 IVb

7

3

4 (57)

6

1 (14)

4

3 (43)

 Not available

3

Lymph node metastasis

0.21³

0.54³

0.11³

 None

87

39

48 (55)

58

29 (33)

55

31 (37)

 Unilateral

44

19

25 (57)

25

19 (43)

29

15 (34)

 Bilateral

24

6

18 (75)

15

9 (38)

10

14 (58)

 Not available

3

Tumor diameter (cm)

0.002¹

0.95¹

0.98¹

 0.3–2.5

32

19

13 (41)

19

13 (41)

20

12 (38)

 2.6–4.0

51

24

27 (53)

33

16 (31)

30

21 (41)

 4.1–20.0

72

21

51 (71)

44

28 (39)

44

28 (39)

 Not available

3

Tumor differentiation

0.07³

0.23³

0.007³

 Well

35

19

16 (46)

26

9 (26)

19

16 (46)

 Moderate

92

32

60 (65)

54

38 (41)

64

28 (30)

 Poor

31

16

15 (48)

21

10 (32)

12

19 (61)

Depth of invasion (mm)

<0.001¹

0.58¹

0.78¹

 0.0–4.0

26

19

7 (27)

17

9 (35)

15

11 (42)

 4.1–8.0

56

26

30 (54)

37

19 (34)

37

19 (34)

 8.1–40.0

74

20

54 (73)

45

29 (39)

43

31 (42)

 Not available

2

Infiltration of vessel

0.55³

0.06³

0.73³

 No

116

51

65 (56)

70

46 (40)

72

44 (38)

 Yes

39

15

24 (62)

30

9 (23)

23

16 (41)

 Not available

3