Figure 1

Mapping of CN losses detected in chromosome 18 by a-CGH analysis. At the top, the location of the EMILIN2, DCC, BCL2, CDH19 genes analyzed by qPCR are indicated by arrows next to an ideogram of chromosome 18 (UCSC Genome Browser). Alterations in cases with detected CN losses are schematically illustrated by bars with red indicating losses and green marking gains. Fifteen samples exhibited loss of the entire chromosome 18, while samples 7, 11, 16, 17, 27P and 31 showed losses restricted to parts of the chromosome. Below are shown a-CGH profiles for case 4 with entire chromosome 18 loss, case 27P with deletion of 18pter-11.21, and case 16 with a 2 Mb deletion at 18q22.1.