Table 3 Univariate and multivariate analyses of prognostic factors including serum E2 level for metastasis-free survival according to ER status
From: Prognostic effect of preoperative serum estradiol level in postmenopausal breast cancer
ER positive group | ER negative group | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||||||
HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | HR | 95% CI | p value | |
Age | 1.06 | 0.97-1.16 | 0.24 | 1.02 | 0.95-1.09 | 0.63 | ||||||
BMI, ≥23 kg/m2 | 1.22 | 0.52-2.86 | 0.64 | 1.02 | 0.37-2.82 | 0.97 | ||||||
HER2/neu positive | 0.99 | 0.98-1.01 | 0.69 | 0.97 | 0.33-2.84 | 0.96 | ||||||
Tumor size, >2 cm | 10.65 | 1.28-88.48 | 0.03 | 3.75 | 0.41-33.98 | 0.24 | 4.75 | 1.07-21.06 | 0.04 | 1.85 | 0.37-9.27 | 0.45 |
Node metastasis | ||||||||||||
0 | Ref. | Ref. | Ref. | |||||||||
1-3 | 1.47 | 0.13-16.25 | 0.75 | 1.12 | 0.10-12.66 | 0.93 | 4.00 | 1.17-13.70 | 0.03 | 2.45 | 0.65-9.31 | 0.19 |
>3 | 18.96 | 3.47-103.63 | 0.001 | 9.05 | 1.50-54.45 | 0.02 | 10.70 | 2.67-42.90 | 0.001 | 2.99 | 0.62-14.36 | 0.17 |
Nuclear grade 3 | 3.06 | 1.06-8.83 | 0.04 | 1.21 | 0.08-19.62 | 0.87 | 1.11 | 0.53-2.34 | 0.78 | |||
Histologic grade 3 | 3.59 | 1.24-10.38 | 0.02 | 8.04 | 0.54-120.81 | 0.13 | 1.16 | 0.55-2.45 | 0.69 | |||
ELTE | 2.91 | 0.65-13.00 | 0.16 | 8.28 | 2.63-26.06 | <0.001 | 4.24 | 1.18-15.18 | 0.03 | |||
E2 level, >13 pg/ml | 2.54 | 0.49-13.13 | 0.27 | 3.373 | 1.07-10.61 | 0.04 | 3.32 | 1.05-10.51 | 0.04 | |||
Chemotherapy | 2.49 | 0.92-6.75 | 0.07 | |||||||||