Figure 4From: Nuclear-encoded mitochondrial MTO1 and MRPL41 are regulated in an opposite epigenetic mode based on estrogen receptor status in breast cancer Opposite effect of estradiol (E2), tamoxifen (TAM), and trichostatin A (TSA) on MTO1 vs. MRPL41 according to estrogen receptor (ER) status in breast cancer cell lines. Cultured cells were treated with E2, TAM, and TSA, and MTO1 (A–C) and MRPL41 (D–F) expression levels were examined by real-time reverse transcription polymerase chain reaction. Gray and black bars represent before and after treatment with the indicated chemical. Each sample was examined in three independent reactions, and the average relative level is presented with the standard error.Back to article page