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Table 1 Molecules in the top ( P = 1.0E-32) network of genes differentially expressed following TIMELESS knockdown

From: Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses

Symbol

RefSeq

Description

Fold change

Q-Value

BMP7

AL567265

Growth factor, may play a role in early development

2.41

5.2E-05

CRKL

NM_005207

Activates the RAS and JUN kinase signaling pathways and transform fibroblast in RAS-dependent fashion, candidate oncogene

-3.04

3.3E-06

CXCL1

NM_001511

Chemokine (C-X-C motif) ligand 1, regulates cell trafficking

2.10

1.4E-04

DMBT1

NM_007329

Plays a role in the interaction of tumor cells and the immune system, candidate tumor suppressor

-5.26

1.3E-12

DTL

NM_016448

Denticleless homolog (Drosophila), required for cell cycle control, DNA damage response and translesion DNA sythesis

-2.34

2.0E-11

EDN1

NM_001955

Endothelin 1, growth factor, involved in tumor progression

4.26

5.8E-32

EMP1

BC017854

Endothelia membrane protein 1

5.33

7.1E-13

EPAS1

NM_001430

Endothelia PAS domain protein 1, transcription factor, involved in the induction of genes regulated by oxygen

3.21

6.7E-11

EPHB6

NM_004445

EPH receptor B6, modulates cell adheson and migration, mediates numerous developmental processes, particularly in the nervous system.

-2.62

2.9E-05

GOS2

NM_015714

G0/G1 switch regulatory protein 2, potential oncogene

3.37

3.8E-09

GDF15

NM_004864

Growth differentiation factor 15, member of the transforming growth factor-beta superfamily, regulates tissue differentiation and maintenance

4.49

3.5E-12

IL8

NM_000584

Interleukin 8, cytokine, inhibits the proliferation of tumor cells

5.10

1.7E-11

KDM3A

NM_018433

May play a role in hormone-dependent transcription acivation and histone code, involved in spermatogenesis and obesity resistance

-2.13

1.5E-08

KRT17

NM_000422

Type I intermediate filament chain keratin 17, may be a marker for basal cell differentiation in complex epithelia

3.45

1.1E-07

LIFR

NM_002310

Leukemia inhibitory factor which is involved in cellular differentiation, proliferation and survival

2.77

2.7E-11

OSM

NM_020530

Cytokine, inhibits the proliferation of a number cell lines

3.23

1.5E-06

PKIA

NM_006823

Protein kinase inhibitor alpha

-3.30

7.2E-09

PODXL

NM_005397

Podocalyxin-like, involved in regulation of both adhesion and cell morphology and cancer progression

-2.47

3.5E-06

PTGFR

NM_000959

Prostaglandin F receptor

5.31

1.1E-08

RGS20

NM_170587

Regulation of G-protein signaling 20, accelarate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination

-3.34

3.4E-08

RHOB

NM_004040

Mediates apoptosis in neo plastically transformed cells after DNA damage, affects cell adhesion and growth factor signaling in transformed cells, involved in intracellular protein trafficking of a number of proteins

2.16

1.2E-04

SOD2

BC016934

Member of the iron/manganese superoxide dismutase family potential tumor suppressor

15.90

2.1E-14

TFPI2

ENST00000222543

Tissue factor pathway inhibitor 2, may play a role in the regulation of plasmin-mediated matrix remodeling

-5.19

4.9E-12

TNFRSF4

NM_003327

Tumor necrosis factor receptor superfamily, member 4, may suppresses apoptosis, plays a role in T cells-dependent B cell proliferation and differentiation

-2.09

8.6E-03

TNFSF4

NM_003326

Tumor necrosis factor (ligand) superfamily, member 4, directly mediates adhesion of activated T cells to vasular endothelial cells

2.18

6.9E-04

TSLP

NM_033035

Thymic stromal lymphopoietin, induces release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendtritic cells

-4.68

8.0E-09