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Figure 1 | BMC Cancer

Figure 1

From: Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses

Figure 1

Microarray data mining of TIMELESS expression in different tumor types. (A) TIMELESS expression in tumor tissues relative to controls from the Oncomine database. 31 out of 32 analyses showed higher TIMELESS expression while 1 analysis found lower TIMELESS expression. Analyses exhibiting P-values < 0.01 and fold-change values ≥ |2| are marked in red and green respectively. The size of each circle is scaled by the sample size of the corresponding analysis. (B) TIMELESS expression in cervical cancer tissue versus preinvasive and normal tissue. Expression of TIMELESS in invasive cervical cancer tissues is significantly higher than in either normal or preinvasive tumor tissues. The original array data are from the Gene Expression Omnibus (accession # GSE7803). (C) TIMELESS expression in breast tumor, adjacent tissues and tissues from healthy controls. TIMELESS expression in breast tissue from healthy controls and adjacent normal tissue was significantly lower than in invasive carcinomas or tissues exhibiting nonproliferative change (cystic change). Original array data is from the ArrayExpress database (accession # E-TABM-276). (D) and (E) TIMELESS expression in prostate tumor and normal tissues. In normal prostate tissue, TIMELESS expression is significantly lower than in primary prostate tumor and metastatic tumor tissues. Metastatic tumor tissue exhibited the highest TIMELESS expression level compared to the other two groups. Original array data are from the Gene Expression Omnibus database (accession #'s GSE21034 and GSE8511).

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