Figure 4
From: Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas
The combined treatment of doxorubicin and salinomycin activates caspase dependent apoptosis. Caspase assays were conducted 14 h, 18 h and 26 h after drug administration for SW872 (A), A204 (B) and HT-1080 (C) cells. The soft tissue sarcoma cells were cultivated with DMSO (black line), 1 μM salinomycin (green line), 125 ng/mL doxorubicin (blue line) and the combination of 1 μM salinomycin with 125 ng/mL doxorubicin (red line). Error bars denote the standard error (n = 3). (* p < 0.05, ** p < 0.01, *** p < 0.001).