TY - JOUR AU - Ghanekar, Anand AU - Ahmed, Sharif AU - Chen, Kui AU - Adeyi, Oyedele PY - 2013 DA - 2013/10/20 TI - Endothelial cells do not arise from tumor-initiating cells in human hepatocellular carcinoma JO - BMC Cancer SP - 485 VL - 13 IS - 1 AB - Conventional models of carcinogenesis suggest that tumors recruit blood vessel formation from normal host tissues. This concept has recently been challenged by prominent studies of glioblastoma, which suggest that intratumoral endothelial cells (ECs) may arise from cancer stem cells/tumor-initiating cells (TICs). Hepatocellular carcinoma (HCC) is a common, highly vascularized tumor with few effective therapies, against which anti-angiogenic strategies are being actively explored. TICs are felt to play a role in HCC pathobiology, but their contributions to tumor vasculature have not been studied. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-13-485 DO - 10.1186/1471-2407-13-485 ID - Ghanekar2013 ER -