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Table 2 Patient’s demographics according to LAT1 expression status

From: Clinical significance of L-type amino acid transporter 1 expression as a prognostic marker and potential of new targeting therapy in biliary tract cancer

Parameter

All patient (n = 139)

Extrahepatic CC (n = 89)

Gallbladder carcinoma (n = 30)

Intrahepatic CC (n = 20)

High(n = 89)

Low (n = 50)

p-value

High (n = 59)

Low (n = 30)

p-value

High (n = 18)

Low (n = 12)

p-value

High (n = 12)

Low (n = 8)

p-value

Age

≤65 / >65

24 / 65

11 / 39

0.549

17 / 42

4 / 26

0.121

3 / 15

2 / 10

>0.999

5 / 7

5 / 3

0.649

Gender

M / F

55 / 34

31 / 19

>0.999

43 / 16

22 / 8

>0.999

4 / 14

4 / 8

0.677

8 / 4

5 / 3

>0.999

Tumor size(mm)

≤35 / >35

48 / 41

28 / 22

0.862

34 / 25

22 / 8

0.170

11 / 7

10 / 2

0.248

4 / 8

4 / 4

0.647

Resection status

R0 / R1

42 / 47

25 / 25

0.859

25 / 34

13 / 17

>0.999

12 / 6

8 / 4

>0.999

5 / 7

5 / 3

0.649

Pathological differentiation

WD or MD / PD

67 / 22

39 / 11

0.572

46 / 13

25 / 5

0.780

16 / 2

11 / 1

0.377

5 / 7

3 / 5

>0.999

Lymphatic permeation

Yes / No

78 / 11

33 / 17

0.003

53 / 6

9 / 21

<0.001

16 / 2

7 / 5

0.459

9 / 3

5 / 3

0.642

Vascular invasion

Yes / No

68 / 21

25 / 25

0.002

49 / 10

17 / 13

0.011

11 / 7

4 / 8

0.263

8 / 4

4 / 4

0.647

Lymph node metastasis

Yes / No

51 / 38

11 / 39

<0.001

33 / 26

8 / 22

0.013

9 / 9

2 / 10

0.121

9 / 3

1 / 7

0.019

Disease staging

I or II / III or IV

64 / 25

45 / 5

0.098

43 / 16

27 / 3

0.099

12 / 6

12 / 0

0.056

9 / 3

6 / 2

>0.999

Papillary pattern

Yes / No

18 / 71

14 / 36

0.302

8 / 51

5 / 25

0.755

10 / 8

8 / 4

0.708

0 / 12

1 / 7

0.400

Adjuvant chemotherapy

Yes / No

40 / 49

11 / 39

0.009

28 / 31

6 / 24

0.012

7 / 11

1 / 11

0.099

5 / 7

4 / 4

>0.999

CEA

≤2.1 / >2.1

45 / 44

29 / 21

0.479

26 / 33

13 / 17

>0.999

11 / 7

7 / 5

>0.999

8 / 4

5 / 3

>0.999

CA19-9

≤45.1 / >45.1

32 / 57

37 / 13

<0.001

22 / 37

23 / 7

<0.001

9 / 9

9 / 3

0.259

5 / 7

5 / 3

0.649

Ki-67

High / Low

47 / 42

15 / 35

0.012

33 / 26

10 / 20

0.072

10 / 8

3 / 9

0.141

4 / 8

2 / 6

>0.999

p53

P / N

48 / 41

23 / 27

0.383

32 / 27

12 / 18

0.263

12 / 6

8 / 4

>0.999

4 / 8

3 / 5

>0.999

CD34

High / Low

51 / 38

18 / 32

0.021

34 / 25

12 / 18

0.124

11 / 7

3 / 9

0.071

6 / 6

3 / 5

0.669

  1. Abbreviation: LAT1 L-type amino acid transporter 1, CC Cholangiocarcinoma, M / F Male / Female, CEA Carcinoembryonic antigen, WD or MD / PD Well differentiated or moderate differentiated / poorly differentiated, P /N Positive / Negative, Bold numbers Statistically significant difference.