Parameter | All patient (n = 139) | Extrahepatic CC (n = 89) | Gallbladder carcinoma (n = 30) | Intrahepatic CC (n = 20) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High(n = 89) | Low (n = 50) | p-value | High (n = 59) | Low (n = 30) | p-value | High (n = 18) | Low (n = 12) | p-value | High (n = 12) | Low (n = 8) | p-value | ||
Age | ≤65 / >65 | 24 / 65 | 11 / 39 | 0.549 | 17 / 42 | 4 / 26 | 0.121 | 3 / 15 | 2 / 10 | >0.999 | 5 / 7 | 5 / 3 | 0.649 |
Gender | M / F | 55 / 34 | 31 / 19 | >0.999 | 43 / 16 | 22 / 8 | >0.999 | 4 / 14 | 4 / 8 | 0.677 | 8 / 4 | 5 / 3 | >0.999 |
Tumor size(mm) | ≤35 / >35 | 48 / 41 | 28 / 22 | 0.862 | 34 / 25 | 22 / 8 | 0.170 | 11 / 7 | 10 / 2 | 0.248 | 4 / 8 | 4 / 4 | 0.647 |
Resection status | R0 / R1 | 42 / 47 | 25 / 25 | 0.859 | 25 / 34 | 13 / 17 | >0.999 | 12 / 6 | 8 / 4 | >0.999 | 5 / 7 | 5 / 3 | 0.649 |
Pathological differentiation | WD or MD / PD | 67 / 22 | 39 / 11 | 0.572 | 46 / 13 | 25 / 5 | 0.780 | 16 / 2 | 11 / 1 | 0.377 | 5 / 7 | 3 / 5 | >0.999 |
Lymphatic permeation | Yes / No | 78 / 11 | 33 / 17 | 0.003 | 53 / 6 | 9 / 21 | <0.001 | 16 / 2 | 7 / 5 | 0.459 | 9 / 3 | 5 / 3 | 0.642 |
Vascular invasion | Yes / No | 68 / 21 | 25 / 25 | 0.002 | 49 / 10 | 17 / 13 | 0.011 | 11 / 7 | 4 / 8 | 0.263 | 8 / 4 | 4 / 4 | 0.647 |
Lymph node metastasis | Yes / No | 51 / 38 | 11 / 39 | <0.001 | 33 / 26 | 8 / 22 | 0.013 | 9 / 9 | 2 / 10 | 0.121 | 9 / 3 | 1 / 7 | 0.019 |
Disease staging | I or II / III or IV | 64 / 25 | 45 / 5 | 0.098 | 43 / 16 | 27 / 3 | 0.099 | 12 / 6 | 12 / 0 | 0.056 | 9 / 3 | 6 / 2 | >0.999 |
Papillary pattern | Yes / No | 18 / 71 | 14 / 36 | 0.302 | 8 / 51 | 5 / 25 | 0.755 | 10 / 8 | 8 / 4 | 0.708 | 0 / 12 | 1 / 7 | 0.400 |
Adjuvant chemotherapy | Yes / No | 40 / 49 | 11 / 39 | 0.009 | 28 / 31 | 6 / 24 | 0.012 | 7 / 11 | 1 / 11 | 0.099 | 5 / 7 | 4 / 4 | >0.999 |
CEA | ≤2.1 / >2.1 | 45 / 44 | 29 / 21 | 0.479 | 26 / 33 | 13 / 17 | >0.999 | 11 / 7 | 7 / 5 | >0.999 | 8 / 4 | 5 / 3 | >0.999 |
CA19-9 | ≤45.1 / >45.1 | 32 / 57 | 37 / 13 | <0.001 | 22 / 37 | 23 / 7 | <0.001 | 9 / 9 | 9 / 3 | 0.259 | 5 / 7 | 5 / 3 | 0.649 |
Ki-67 | High / Low | 47 / 42 | 15 / 35 | 0.012 | 33 / 26 | 10 / 20 | 0.072 | 10 / 8 | 3 / 9 | 0.141 | 4 / 8 | 2 / 6 | >0.999 |
p53 | P / N | 48 / 41 | 23 / 27 | 0.383 | 32 / 27 | 12 / 18 | 0.263 | 12 / 6 | 8 / 4 | >0.999 | 4 / 8 | 3 / 5 | >0.999 |
CD34 | High / Low | 51 / 38 | 18 / 32 | 0.021 | 34 / 25 | 12 / 18 | 0.124 | 11 / 7 | 3 / 9 | 0.071 | 6 / 6 | 3 / 5 | 0.669 |