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Table 1 Determined IC50 values for enediyne-energized fusion proteins in HMEC and different cancer cell lines

From: Genetically engineered endostatin-lidamycin fusion proteins effectively inhibit tumor growth and metastasis

Cells

IC50(M)

 

HMEC

PG-BE1

4T1

LDM

1.16 ± 0.39 × 10-10

1.01 ± 0.24 × 10-9

2.79 ± 0.41 × 10-10

ES-LDP-AE

8.13 ± 0.98 × 10-10

8.06 ± 2.06 × 10-10

2.05 ± 0.67 × 10-10

LDP-ES-AE

1.14 ± 0.39 × 10-9

2.61 ± 0.14 × 10-9

2.94 ± 0.80 × 10-9