Figure 7
ES-LDP treatment inhibits the lung metastasis of 4T1-luc tumors. 4T1-luc cells (2 × 105) were injected intravenously into mice. Mice were given ES (36 mg/kg body weight) or ES-LDP (54 mg/kg body weight) twice, and saline served as control. At the end of the experiment, mice were injected with D-luciferin and bioluminescence imaging was done. Then, animals were killed and lungs were harvested and weighed before evaluation of the surface metastasis. (A) The profile of optical imaging from different experimental groups. ES-LDP-treated mice showed both significantly reduced surface metastasis (B) and lung weight gain (C) in comparison to the control animals. (* P < 0.05,** P < 0.01; compared to control, respectively).