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Figure 5 | BMC Cancer

Figure 5

From: Chemotherapy-induced hyaluronan production: a novel chemoresistance mechanism in ovarian cancer

Figure 5

HA is increased following chemotherapy treatment. A. HA serum levels in ovarian cancer patients at diagnosis (cancer; n = 101), after at least 2 cycles of chemotherapy (post chemotherapy; n = 52), and at 1st recurrence n = 17) and 2nd recurrence (n = 5), as well as serum from patients with benign ovarian tumors (benign; n = 22) and from healthy controls (normal; n = 27). *, significantly different from normal control (P < 0.05, Mann Whitney U test). **, significantly different from HA serum level at diagnosis (P < 0.05, Mann Whitney U test). The bars specify the median values in each group. B. Fold change in serum HA levels in matched ovarian cancer patients at diagnosis and following chemotherapy treatment (n = 32). *, significantly increased from level at diagnosis (Wilcoxon rank test, P < 0.0001). HA staining in representative ovarian cancer tissues prior to treatment (C), post chemotherapy (D) and at recurrence (E). Ep = cancer cells, St = peritumoral stroma. Bar = 100 μm.

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