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Table 7 Association of body size with postmenopausal breast cancer by hormone receptor status

From: Body fatness and breast cancer risk in women of African ancestry

  

ER+/PR+ vs. controls

ER-/PR- vs. controls

ER-/PR- cases vs. ER+/PR+ cases

 

CO

CA

OR

95% CI

CA

OR

95% CI

OR

95% CI

Current BMI*

         

  Underweight/Normal (<25)

68

26

Ref

 

20

Ref

 

Ref

 

  Overweight (25-29.99)

132

49

1.05

0.55–1.98

34

0.77

0.38–1.59

0.88

0.36–2.13

  Obese (≥30)

276

131

1.04

0.50–2.18

47

0.37

0.15–0.96

0.42

0.14–1.25

   p for trend

   

0.95

  

0.03

 

0.07

% Body fat

         

  ≤35.9

94

34

Ref

 

23

Ref

 

Ref

 

  36–41.6

107

39

1.04

0.57–1.89

29

1.41

0.70–2.85

1.37

0.58–3.22

  41.7–46.5

124

62

1.38

0.74–2.58

19

0.70

0.30–1.62

0.57

0.21–1.52

  >46.5

119

57

1.39

0.62–3.12

25

1.39

0.49–3.99

1.11

0.33–3.73

   p for trend

   

0.32

  

0.92

 

0.75

Waist to hip ratio

         

  ≤0.82

93

25

Ref

 

18

Ref

 

Ref

 

  0.83–0.87

117

57

1.71

0.95–3.07

26

1.12

0.56–2.26

0.65

0.26–1.57

  0.88–0.92

116

53

1.55

0.85–2.81

17

0.61

0.28–1.33

0.36

0.14–0.95

  >0.92

144

70

1.61

0.90–2.90

39

1.26

0.63–2.50

0.63

0.27–1.50

   p for trend

   

0.27

  

0.63

 

0.38

Waist circumference (cm)

         

  ≤87.88

94

36

Ref

 

23

Ref

 

Ref

 

  87.89–97.75

118

39

0.88

0.48–1.60

25

0.93

0.45–1.92

1.14

0.48–2.73

  97.76–110.25

121

56

1.30

0.68–2.48

25

1.11

0.48–2.57

0.95

0.36–2.45

  >110.25

137

74

1.55

0.68–3.55

27

1.08

0.35–3.31

0.59

0.17–2.03

   p for trend

   

0.20

  

0.83

 

0.34

Hip circumference (cm)

         

  ≤103.18

99

47

Ref

 

24

Ref

 

Ref

 

  103.19–111.63

126

42

0.72

0.40–1.28

33

1.29

0.64–2.59

2.10

0.90–4.89

  111.64–123.15

122

56

0.91

0.48–1.72

23

1.06

0.45–2.48

1.43

0.51–4.03

  >123.15

123

60

0.73

0.31–1.73

20

1.00

0.31–3.29

1.89

0.45–7.98

   p for trend

   

0.65

  

0.81

 

0.61

  1. *BMI measured at interview.
  2. Abbreviations: CO number of controls, CA number of cases, ER estrogen receptor, PR progesterone receptor.
  3. Adjusted for age, ethnicity, country of origin (United States, Caribbean, other), education, family history of breast cancer, history of benign breast disease, age at menarche, age at menopause (for postmenopausal women), parity (continuous), breastfeeding (yes/no), age at first birth, HRT use (ever/never), OC use (ever/never). BMI also adjusted for waist circumference. Percent body fat, waist circumference, and hip circumference, also adjusted for BMI. For postmenopausal women, percent body fat adjusted for years since menopause instead of age at menopause.
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BMC Cancer

ISSN: 1471-2407

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