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Table 5 Association of body size and breast cancer risk among non-HRT users (excluding n = 267 HRT users)

From: Body fatness and breast cancer risk in women of African ancestry

 

Pre-menopausal

Post-menopausal

 

Cases/Controls

OR1

95% CI

OR2

95% CI

Cases/Controls

OR1

95% CI

OR2

95% CI

Current BMI*

          

  Underweight/Normal (<25)

96/102

Ref

 

Ref

 

55/53

Ref

 

Ref

 

 Overweight (25–29.99)

147/136

1.09

0.74–1.61

1.12

0.74–1.69

86/107

0.76

0.46–1.26

0.77

0.46–1.31

 Obese (≥30)

206/229

0.91

0.63–1.32

0.92

0.54–1.58

234/218

0.97

0.62–1.52

1.05

0.57–1.95

  p for trend

  

0.41

 

0.60

  

0.56

 

0.49

% Body Fat

          

 ≤35.9

139/133

Ref

 

Ref

 

69/73

Ref

 

Ref

 

 36–41.6

112/114

0.90

0.62–1.31

0.98

0.65–1.46

85/86

1.05

0.66–1.68

1.18

0.72–1.95

 41.7–46.5

94/101

0.89

0.60–1.32

1.03

0.63–1.66

90/95

0.87

0.54–1.39

1.06

0.61–1.84

 >46.5

79/103

0.81

0.53–1.22

1.08

0.54–2.17

102/96

1.03

0.65–1.64

1.49

0.74–2.99

  p for trend

  

0.31

 

0.88

  

0.94

 

0.38

Waist to hip ratio

          

 ≤0.82

118/144

Ref

 

Ref

 

52/70

Ref

 

Ref

 

 0.83–0.87

122/113

1.21

0.83–1.77

1.27

0.87–1.86

97/94

1.16

0.72–1.88

1.17

0.72–1.90

 0.88–0.92

100/116

1.02

0.69–1.52

1.11

0.74–1.67

78/88

0.97

0.58–1.59

0.99

0.60–1.64

 >0.92

100/90

1.22

0.80–1.84

1.38

0.89–2.14

140/121

1.29

0.81–2.06

1.34

0.83–2.16

  p for trend

  

0.51

 

0.22

  

0.35

 

0.28

Waist circumference (cm)

          

 ≤87.88

130/140

Ref

 

Ref

 

62/75

Ref

 

Ref

 

 87.89–97.75

120/114

1.04

0.71–1.50

1.25

0.83–1.88

82/91

1.04

0.64–1.67

1.18

0.70–1.97

 97.76–110.25

102/112

0.94

0.64–1.39

1.40

0.83–2.35

114/98

1.39

0.87–2.20

1.74

0.99–3.06

 >110.25

88/97

0.98

0.64–1.50

2.01

0.95–4.29

109/109

1.08

0.68–1.72

1.64

0.77–3.50

  p for trend

  

0.84

 

0.08

  

0.61

 

0.14

Hip circumference (cm)

          

 ≤103.18

120/134

Ref

 

Ref

 

76/81

Ref

 

Ref

 

 103.19–111.63

129/107

1.28

0.88–1.86

1.60

1.06–2.41

89/98

1.06

0.68–1.68

1.14

0.70–1.86

 111.64–123.15

95/113

0.97

0.65–1.43

1.50

0.91–2.46

112/98

1.31

0.84–2.04

1.47

0.85–2.56

 >123.15

97/109

1.10

0.74–1.65

2.78

1.32–5.88

90/96

0.97

0.61–1.54

1.22

0.56–2.62

  p for trend

  

0.92

 

0.02

  

0.92

 

0.65

  1. *BMI measured at interview.
  2. OR1: Adjusted for age, ethnicity, country of origin (United States, Caribbean, other), education, family history of breast cancer, history of benign breast disease, age at menarche, age at menopause (for postmenopausal women), parity (continuous), breastfeeding (yes/no), age at first birth, OC use (ever/never). OR2: BMI further adjusted for waist circumference. Percent body fat, waist circumference and hip circumference, further adjusted for BMI. Percent body fat adjusted for years since menopause instead of age at menopause.
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BMC Cancer

ISSN: 1471-2407

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