Overall survival and toxicities regarding thoracic three-dimensional radiotherapy with concurrent chemotherapy for stage IV non-small cell lung cancer: results of a prospective single-center study

Table 2 Multivariate analysis of parameters for the prediction of overall survival

Variable	All patients		Patients with single sites of metastasis		Patients with ≥2 sites of metastasis
Variable	HR	Pvalue	HR	Pvalue	HR	Pvalue
Sex(female vs. male)	0.742	0.117	0.605	0.079	0.786	0.201
Age(<60y vs. ≥60y)	0.841	0.288	0.915	0.740	0.856	0.340
Pathological type (squamous vs. non-squamous )	0.991	0.957	0.919	0.767	0.973	0.872
T stage(T3-4 vs. T1-2)	1.109	0.537	1.178	0.667	1.188	0.296
N stage(N2-3 vs. N0-1)	1.286	0.232	1.213	0.597	1.305	0.208
Thoracic radiation dose	0.615	0.007	0.576	0.045	0.619	0.008
(≥63Gy vs. <63Gy)	0.615	0.007	0.576	0.045	0.619	0.008
Radiotherapy to metastases(yes vs. no)	0.729	0.063	0.340	0.001	0.674	0.017
Chemotherapy cycles	0.693	0.038	0.625	0.079	0.691	0.039
(≥4 cycles vs. < 4 cycles)	0.693	0.038	0.625	0.079	0.691	0.039
Metastasis status	1.513	0.014	-	-	-	-
(multi- vs. single)	1.513	0.014	-	-	-	-

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