Cell cycle genes affected in estrogen deprived cells. Red and blue boxes indicate up- and down regulated gene expression in response to estrogen deprivation relative to untreated control. Small circles (red and blue) mark a statistically significant increase or decrease in expression. (A) MCF7 cells at 2 days after estrogen deprivation versus control cells. (B) BT474 cells at 6 weeks after estrogen deprivation versus control cells.