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Figure 3 | BMC Cancer

Figure 3

From: Prognostic significance and therapeutic potential of the activation of anaplastic lymphoma kinase/protein kinase B/mammalian target of rapamycin signaling pathway in anaplastic large cell lymphoma

Figure 3

Overexpression of NPM-ALK in BaF3 cells induced their cytokine independent growth and resistance to dexamethasone treatment. (A) NPM-ALK confers IL-3-independent growth to BaF3 cells. Stably transfected BaF3 cells expressing NPM-ALK were assessed for growth in the presence or absence of IL-3, together with empty vector-containing cells. Viable cell counts were performed in triplicate using trypan blue at 24-hour intervals, with each point being the average of the triplicate measurements. (B) BaF3 cells transformed by NPM-ALK became resistant to GCs and could survive well in 1 μM Dex, while BaF3 cells transfected with empty vector could not proliferate at this concentration.

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BMC Cancer

ISSN: 1471-2407

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