| |
Day 1
|
Day 22
|
|---|
|
Dose, mg/m2
|
Patients treated/with data
|
Cmax,
aμg/l
|
AUC0–t, μg.h/l
|
Patients treated/with data
|
Cmax,
aμg/l
|
AUC0–t, μg.h/l
|
|---|
|
1.5
|
1/1
|
15.5
|
17.2
|
1/1
|
13.5
|
28.2
|
|
3
|
1/1
|
41.9
|
47.1
|
1/1
|
23.0
|
102
|
|
6
|
4/3
|
31.2 ± 15.5 (50)
|
89.7 ± 51.8 (58)
|
4/3
|
49.4 ± 13.8 (28)
|
150 ± 34 (22)
|
|
8.4
|
12/11
|
71.7 ± 54.4 (76)
|
144 ± 46 (32)
|
11/9
|
70 ± 30.4 (43)
|
190 ± 89 (47)
|
|
10
|
7/4
|
102 ± 52 (51)
|
153 ± 91 (60)
|
4/4
|
89.3 ± 80.6 (90)
|
187 ± 56 (30)
|
|
12
|
6/3
|
152 ± 148 (97)
|
212 ± 120 (56)
|
4/2
|
84.8–480
|
145–447
|
- Data are expressed as mean ± SD (CV%).
-
a Observed value at 5 minutes before the end of infusion except for four patients on Days 1 and for seven patients on Day 22 for whom maximal plasma concentrations were measured 20 minutes before the end of infusion.
