Table 4 Association between HPV16 E6 and LCR gene and CIN2/3 in 304 women
No. of isolates with disease grade (%) n=304 | ||||
|---|---|---|---|---|
Variable | <CIN2,3 (n = 137) | ≥ CIN2,3 (n =167) | Crude OR (95% CI)* | Adjusted OR (95% CI) * |
Number of HPV types per sample | ||||
No. of types (median) | 2 | 3 | 1.1 (0.9–1.4) | nd |
EUR lineage | 113(82.5) | 78(46.7) | 5.0 (2.9-8.3) | 5.8(3.2-9.4) |
E-350G/T | 13(11.5) | 17(21.8) | 0.5(0.2-1.0) | nd |
E-94G/A | 17(15.0) | 18(23.1) | 0.6(0.3-1.2) | nd |
As lineage | 24(17.5) | 89(53.3) | 0.2 (0.1-0.3) | 0.3(0.2-0.8) |
As-131A/C | 9(37.5) | 23(25.9) | 1.4(0.4-3.4) | nd |
E6 variations | ||||
Referent variants | 84 (61.3) | 88 (52.6) | 1.0(reference) | 1.0(reference) |
R10G/ L83V | 1(0.7) | 8(4.8) | 0.1(0.0-1.0) | 0.1(0.1-0.9) |
LCR variations | ||||
Referent variants | 137 (100) | 167 (100) | 1.0(reference) | 1.0(reference) |
Co-variation of C7294Ta | 4 (1.5) | 18 (10.8) | 0.2 (0.1-0.6) | 5.7(0.1-0.7) |