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Table 6 Multivariate survival analysis - continuous methylation data

From: Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors

Covariate Baseline Coefficient (bi) HR(exp(bi) p-value 95,0% CI for Exp(B)
GSTP1 Normal like GSTP1 −0.066 0.935 4e-4 (0.902-0.970)
IGF2 Normal like IGF2 0.079 1.082 0.002 (1.031-1.136)
MLH1 Normal like MLH1 −0.552 0.575 0.135 (0.278-1.187)
ER ER positive 1.659 5.256 0.002 (1.804-15.317)
TP53 TP53 wild type −2.169 0.114 0.002 (0.028-0.450)
N 1 N0 1.684 5.391 0.022 (1.265-22.975)
N 2 N0 1.706 5.511 0.032 (1.151-26.371)
T 2 T1 1.937 6.942 0.035 (1.143-42.157)
T3 T1 0.050 1.051 0.960 (0.143-7.716)
T4 T1 1.125 3.081 0.258 (0.437-21.692)
  1. The variables that the minimum AIC selected. ( p-values: 1.2e-7 for likelihood ratio test, 5.8e-4 for Wald test, 6.7e-6 for log-rank test).
  2. Positive hazard ratios indicate an increased risk of dying from breast cancer and are calculated for the different covariates.