|
Normal
| |
DCIS
|
Invasive
|
---|
| |
I
| |
II
| |
III
| |
IV
| |
---|
GENE
|
Methylation status
|
N
|
%
|
Sample number
|
%
|
Sample number
|
%
|
Sample number
|
%
|
Sample number
|
%
|
Sample number
|
%
|
ABCB1
|
Hypomethylated
|
0
|
0
|
0
| |
0
| |
0
| |
0
| |
0
| |
Normal like
|
6
|
100
|
15
|
57.7
|
33
|
52.4
|
6
|
30
|
31
|
36
|
6
|
30
|
Hypermethylated
|
0
| |
11
|
42.3
|
30
|
47.6
|
14
|
70
|
57
|
64
|
14
|
70
|
BRCA1
|
Hypomethylated
|
0
|
0
|
0
|
0
|
2
|
3
|
2
|
10
|
10
|
12.8
|
1
|
5.9
|
Normal like
|
6
|
100
|
26
|
100
|
63
|
97
|
18
|
90
|
68
|
87.2
|
16
|
94.1
|
Hypermethylated
|
0
| |
0
|
0
|
0
| |
0
| |
0
| |
0
| |
CDKN2A
|
Hypomethylated
|
0
|
0
|
0
|
0
|
0
| |
0
| |
0
| |
0
| |
Normal like
|
6
|
100
|
26
|
100
|
60
|
92.3
|
18
|
90
|
61
|
67.8
|
14
|
70
|
Hypermethylated
|
0
| |
0
| |
5
|
7.7
|
2
|
10
|
29
|
32.2
|
6
|
30
|
ESR1
|
Hypomethylated
|
0
|
0
|
0
|
0
|
0
| |
0
| |
0
| |
0
|
0
|
Normal like
|
6
|
100
|
26
|
100
|
63
|
97
|
19
|
95
|
63
|
98.4
|
19
|
100
|
Hypermethylated
|
0
| |
0
| |
2
|
3
|
1
|
5
|
1
|
1.6
|
0
| |
FOXC1
|
Hypomethylated
|
0
|
0
|
0
| |
0
| |
0
| |
0
| |
0
| |
Normal like
|
6
|
100
|
6
|
23
|
34
|
52.3
|
7
|
35
|
40
|
46.5
|
10
|
47.6
|
Hypermethylated
|
0
| |
20
|
77
|
31
|
47.7
|
13
|
65
|
46
|
53.5
|
11
|
52.4
|
GSTP1
|
Hypomethylated
|
0
|
0
|
1
|
3.8
|
0
| |
0
| |
0
| |
0
| |
Normal like
|
6
|
100
|
10
|
38.5
|
27
|
41.5
|
5
|
25
|
29
|
33
|
5
|
25
|
Hypermethylated
|
0
| |
15
|
57.7
|
38
|
58.5
|
15
|
75
|
59
|
67
|
15
|
75
|
IGF2
|
Hypomethylated
|
0
|
0
|
11
|
42.3
|
25
|
38.4
|
6
|
30
|
34
|
39.1
|
9
|
47.4
|
Normal like
|
6
|
100
|
14
|
53.8
|
32
|
49.2
|
9
|
45
|
32
|
36.8
|
5
|
26.3
|
Hypermethylated
|
0
|
0
|
1
|
3.9
|
8
|
12.4
|
5
|
25
|
21
|
24.1
|
5
|
26.3
|
MGMT
|
Hypomethylated
|
0
|
0
|
0
| |
13
|
20.3
|
13
|
65
|
16
|
24.2
|
8
|
44.4
|
Normal like
|
6
|
100
|
25
|
96.1
|
50
|
78.1
|
5
|
25
|
35
|
53.1
|
5
|
27.7
|
Hypermethylated
|
0
| |
1
|
3.9
|
1
|
11.6
|
2
|
10
|
15
|
22.7
|
5
|
27.7
|
MLH1
|
Hypomethylated
|
0
|
0
|
4
|
15.4
|
12
|
18.5
|
6
|
32
|
4
|
4.5
|
3
|
17.6
|
Normal like
|
6
|
100
|
21
|
80.8
|
47
|
72.3
|
10
|
53
|
68
|
77.3
|
13
|
76.5
|
Hypermethylated
|
0
| |
1
|
3.8
|
6
|
9.2
|
3
|
16
|
16
|
18.2
|
1
|
5.9
|
PPP2R2B
|
Hypomethylated
|
0
|
0
|
0
| |
0
| |
0
| |
0
| |
0
| |
Normal like
|
6
|
100
|
7
|
26.9
|
15
|
24.6
|
6
|
35
|
40
|
30.8
|
3
|
16.7
|
Hypermethylated
|
0
| |
19
|
73.1
|
46
|
75.4
|
11
|
65
|
45
|
69.2
|
15
|
83.3
|
PTEN
|
Hypomethylated
|
0
|
0
|
0
| |
0
| |
0
| |
0
| |
0
| |
Normal like
|
6
|
100
|
21
|
80.8
|
56
|
86.2
|
13
|
65
|
23
|
27.7
|
9
|
45
|
Hypermethylated
|
0
| |
5
|
19.2
|
9
|
13.8
|
7
|
35
|
60
|
72.3
|
11
|
55
|
RASSF1A
|
Hypomethylated
|
0
|
0
|
2
|
7.7
|
2
|
3.1
|
1
| |
0
| |
0
| |
Normal like
|
6
|
100
|
2
|
7.7
|
10
|
15.4
|
2
|
11
|
3
|
4.8
|
1
|
5.6
|
Hypermethylated
|
0
| |
22
|
84.6
|
53
|
81.5
|
17
|
90
|
60
|
95.2
|
17
|
94.4
|
- Samples were considered as hypermethylated if the% DNA methylation was higher than the sum of two times the standard deviation and mean of the normal samples and hypomethylated if% DNA methylation was lower than two times the standard deviation - mean of the normal samples.