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Table 1 Biological processes associated with HOXB7 transcript inhibition in MIA PaCa-2 cell lineage

From: HOXB7 mRNA is overexpressed in pancreatic ductal adenocarcinomas and its knockdown induces cell cycle arrest and apoptosis

Biological process

Cellular macromolecular complex assembly

C=336;O=32;E=13.19;R=2.43;rawP=3.34e-06;adjP=0.0012

Macromolecular complex subunit organization

C=741;O=55;E=29.09;R=1.89;rawP=3.63e-06;adjP=0.0012

Macromolecular complex assembly

C=672;O=51;E=26.38;R=1.93;rawP=4.49e-06;adjP=0.0012

Organelle organization

C=1339;O=87;E=52.57;R=1.66;rawP=1.38e-06;adjP=0.0012

Cellular macromolecular complex subunit organization

C=396;O=36;E=15.55;R=2.32;rawP=2.42e-06;adjP=0.0012

Protein complex assembly

C=520;O=42;E=20.41;R=2.06;rawP=7.28e-06;adjP=0.0014

Protein complex biogenesis

C=520;O=42;E=20.41;R=2.06;rawP=7.28e-06;adjP=0.0014

Cellular protein complex assembly

C=184;O=21;E=7.22;R=2.91;rawP=1.12e-05;adjP=0.0019

Proteasomal ubiquitin-dependent protein catabolic process

C=107;O=15;E=4.20;R=3.57;rawP=1.79e-05;adjP=0.0022

Proteasomal protein catabolic process

C=107;O=15;E=4.20;R=3.57;rawP=1.79e-05;adjP=0.0022

Interspecies interaction between organisms

C=280;O=27;E=10.99;R=2.46;rawP=1.56e-05;adjP=0.0022

Cell cycle

C=895;O=60;E=35.14;R=1.71;rawP=2.98e-05;adjP=0.0033

Amine biosynthetic process

C=78;O=12;E=3.06;R=3.92;rawP=4.83e-05;adjP=0.0050

Positive regulation of ubiquitin-protein ligase activity

C=67;O=11;E=2.63;R=4.18;rawP=5.37e-05;adjP=0.0052

Positive regulation of ligase activity

C=70;O=11;E=2.75;R=4.00;rawP=8.13e-05;adjP=0.0073

Chromatin organization

C=364;O=30;E=14.29;R=2.10;rawP=0.0001;adjP=0.0084

  1. C- Reference genes in the category, O- number of genes in the gene set and also in the category, E- expected number in the category, R- ratio of enrichment, rawP- p value from hypergeometric test, adjP- p value adjusted by the multiple test adjustment.
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BMC Cancer

ISSN: 1471-2407

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