Table 2 Univariate survival analysis for Sirt1 expression and clinico-pathological parameters in PDAC
From: High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
| Â | Â | Cases | Events | Mean survival (months) | Standard error | Log-rank-test (p-value) |
|---|---|---|---|---|---|---|
Age at diagnosis | <=65Â years | 56 | 42 | 50.1 | 10.5 | 0.564 |
| Â | >65Â years | 57 | 47 | 25.1 | 4.4 | Â |
WHO stage | I | 11 | 8 | 29.4 | 9.8 | 0.001 |
| Â | IIA | 17 | 10 | 52.8 | 11.9 | Â |
| Â | IIB | 78 | 64 | 33.7 | 7.0 | Â |
| Â | III | 3 | 3 | 5.6 | 0.8 | Â |
| Â | IV | 4 | 4 | 11.9 | 4.1 | Â |
Tumor stage | T1 | / | / | / | / | Â |
| Â | T2 | 22 | 17 | 29.6 | 6.8 | 0.003 |
| Â | T3 | 88 | 69 | 39.6 | 7.3 | Â |
| Â | T4 | 3 | 3 | 5.6 | 0.8 | Â |
Nodal status | N0 | 30 | 20 | 43.3 | 8.8 | 0.060 |
| Â | N1 | 83 | 69 | 32.2 | 6.6 | Â |
State of metastasis | M0 | 109 | 85 | 42.4 | 6.8 | 0.268 |
| Â | M1 | 4 | 4 | 11.9 | 4.1 | Â |
Grade | G1 | 7 | 6 | 16.8 | 2.5 | 0.058 |
| Â | G2 | 54 | 39 | 37.3 | 6.0 | Â |
| Â | G3 | 52 | 44 | 29.7 | 7.9 | Â |
SIRT1-expression | low | 81 | 58 | 54.1 | 8.9 | 0.002 |
| Â | high | 32 | 31 | 13.0 | 1.7 | Â |