Table 1 Clinico-pathological characteristics of the PDAC study cohort: correlation with Sirt1 expression
From: High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma
Characteristics | All cases | SIRT1 low | SIRT1 high | p-value |
|---|---|---|---|---|
All cases | Â | Â | Â | Â |
| Â | 129 | 93 (72.1%) | 36 (27.9%) | Â |
Age | Â | Â | Â | 0.401 |
≤65 years | 65 (50.4%) | 48 (73.8%) | 17 (26.2%) | |
>65Â years | 64 (49.6%) | 48 (70.3%) | 17 (29.7%) | |
WHO stage | Â | Â | Â | 0.871 |
I | 12 (9.3%) | 9 (75%) | 3 (25%) | |
IIA | 17 (13.2%) | 13 (76.5%) | 4 (23.5%) | |
IIB | 91 (70.5%) | 66 (72.5%) | 25 (27.5%) | |
III | 5 (3.9%) | 3 (60.0%) | 2 (40.0%) | |
IV | 4 (3.1%) | 2 (50.0%) | 2 (50.0%) | |
Tumour stage | Â | Â | Â | 0.793 |
T1 | / | / | / | |
T2 | 24 (18.6%) | 18 (75.0%) | 6 (25.0%) | |
T3 | 100 (77.5%) | 72 (72.0%) | 28 (28.0%) | |
T4 | 5 (3.9%) | 3 (60.0%) | 2 (40.0%) | |
Nodal status | Â | Â | Â | 0.520 |
N0 | 31 (24.0%) | 22 (71.0%) | 9 (29.0%) | |
N1 | 98 (76.0%) | 71 (72.4%) | 27 (27.6%) | |
State of metastasis | Â | Â | Â | 0.310 |
M0 | 125 (96.9%) | 91 (72.8%) | 34 (27.2%) | |
M1 | 4 (3.1%) | 2 (50.0%) | 2 (50.0%) | |
Grade | Â | Â | Â | 0.001 |
G1 | 8 (6.2%) | 6 (75.0%) | 2 (25.0%) | |
G2 | 64 (49.6%) | 55 (85.9%) | 9 (14.1%) | |
G3 | 57 (44.2%) | 32 (56.1%) | 25 (43.9%) |