Impacts of clinicopathologic and operative factors on short-term and long-term survival in renal cell carcinoma with venous tumor thrombus extension: a multi-institutional retrospective study in Japan

Table 6 Impact of follow-up duration on overall survival in patients with renal cell carcinoma extending into venous system: Multivariate logistic regression analyses using restricted follow-up data until 1, 2, and 3 years after intervention

Variables	Estimate	±	Standard error	Odds ratio		p value
Variables	Estimate	±	Standard error	(95% Confident interval)		p value
Restricted follow-up until 1 year
Surgical category	0.71	±	0.19	2.03	(1.40-2.92)	0.00016
RV/IVC wall invasion status	1.06	±	0.39	2.87	(1.33-6.20)	0.00721
Tumor size	0.69	±	0.40	1.98	(0.91-4.34)	0.08591
Constant	-4.15	±	0.78
Restricted follow-up until 2 years
LDH	2.48	±	0.94	11.96	(1.91-75.0)	0.00804
Surgical category	1.95	±	0.52	7.04	(2.56-19.4)	0.00016
RV/IVC wall invasion status	1.99	±	0.79	7.28	(1.56-34.0)	0.01152
α2 globulin	1.69	±	0.80	5.44	(1.14-25.9)	0.03351
Constant	-12.10	±	2.86
Restricted follow-up until 3 years
LDH	1.02	±	0.49	2.78	(1.07-7.25)	0.03621
Surgical category	0.86	±	0.26	2.36	(1.42-3.92)	0.00090
α2 globulin	1.62	±	0.51	5.05	(1.84-13.8)	0.00164
Constant	-8.48	±	1.75

In the stepwise multiple regression analysis, 3.2-10.5% α2 globulin, 66–288 U/l LDH, radical nephrectomy and complete resection of thrombus without metastasis in surgical category, <8.3-cm tumor size, and non-venous wall-invasive thrombus in RV/IVC wall invasion are coded as 1.
Similarly, 10.6-22.3% α2 globulin, 289–1740 U/l LDH, radical nephrectomy and complete resection of thrombus with metastases that has undergone a cytoreductive surgery in surgical category, 8.5-27.0-cm tumor size, and venous wall-invasive thrombus in RV/IVC wall invasion are coded as 2.
Radical nephrectomy and complete resection of thrombus with unresected metastases, radical nephrectomy and incomplete resection of thrombus regardless of metastatic status, and abandoned operation in surgical category are coded as 3, 4, and 5, respectively.

ISSN: 1471-2407