Skip to main content

Table 4 Impacts of various pretreatment, treatment, and pathological factors on overall survival

From: Impacts of clinicopathologic and operative factors on short-term and long-term survival in renal cell carcinoma with venous tumor thrombus extension: a multi-institutional retrospective study in Japan

Variables

All

5 years

Statistical significance

 

n

Events (all death)

No. of patients at risk

Events (all death)

Cumulative rate(%)

S.E.

All cases

292

147

68

14

47.6%

3.3%

 

Operation volume in each hospital (n)

1-9

29

13

3

1

40.9%

14.1%

ns; any comparison

10-19

75

35

21

4

50.4%

6.5%

 

20-35

188

99

44

9

46.9%

4.1%

 

Treatment era

Before 1999

144

86

56

8

49.2%

4.4%

ns

After 2000

148

61

12

6

43.4%

5.7%

 

Age (years old)

30-57

100

49

26

5

48.2%

5.6%

p = 0.00561; Age 58–67 vs. Age 68-87

58-67

96

45

33

5

58.6%

5.5%

 

68-87

96

53

9

4

34.2%

6.1%

 

Performance status

0

197

82

47

8

55.8%

4.1%

p = 0.00002

1-4

60

41

10

4

25.7%

6.4%

 

Operation

Yes

281

136

68

14

49.7%

3.4%

p = 0.00000

No

11

11

0

0

   

ESR (mm/h)

Male: 0–49, female: 0-52

91

38

25

5

55.4%

6.0%

p = 0.00024

Male:> = 50, female:> = 56

92

60

12

4

29.4%

5.7%

 

CRP (mg/l)

<1.3

129

47

33

5

61.0%

5.0%

p = 0.00003

> = 1.3

126

78

21

7

32.9%

4.9%

 

α2 globulin (%)

3.2-10.5

76

27

20

5

60.9%

6.5%

p = 0.00212

10.6-22.3

76

44

15

3

38.4%

6.6%

 

Ca (mg/dl)

3.8-9.1

99

49

24

4

49.1%

5.7%

ns

9.2-14.1

100

45

20

4

49.7%

5.9%

 

LDH (U/l)

66-288

126

46

21

7

51.1%

6.0%

p = 0.02171

289-1740

125

78

34

6

42.2%

4.7%

 

Hb (g/dl)

6.5-11.3

107

64

19

7

32.5%

5.5%

p = 0.00250

11.4-18.5

103

45

27

2

57.7%

5.5%

 

IAP (μg/ml)

232-712

102

36

32

5

64.5%

5.3%

p = 0.00000

713-2048

101

65

13

5

29.8%

5.5%

 

T_category

= < T3

275

134

68

13

49.8%

3.4%

p = 0.00000

T4

14

12

0

1

9.5%

8.8%

 

N_category

N0

118

55

32

6

55.8%

5.0%

p = 0.00000

N1 + N2

61

41

3

4

13.0%

5.9%

 

M_category

M0

183

83

44

11

51.3%

4.3%

p = 0.00002

M1

91

61

14

3

31.4%

5.3%

 

Surgical category

1

196

82

52

11

55.5%

4.1%

p = 0.00007; surgical category 1 vs. surgical category 3

2

11

6

4

2

52.0%

15.7%

p = 0.00022; surgical category 1 vs. surgical category 4

3

66

41

10

1

34.7%

6.6%

p = 0.00000; surgical category 1 vs. surgical category 5

4

8

7

2

0

25.0%

15.3%

p = 0.00342; surgical category 2 vs. surgical category 5

5

11

11

0

0

  

p = 0.00112; surgical category 3 vs. surgical category 5

Tumor size (cm)

0-8.3

141

60

41

7

59.6%

4.8%

p = 0.0020

2:8.5-27

139

78

24

7

36.6%

4.7%

 

Pathological subtype

Clear cell

206

90

55

11

54.8%

3.9%

p = 0.02816; clear cell vs. papillary, chromophobe, others

Papillary, chromophobe, others

56

31

11

2

41.9%

7.6%

p = 0.00000; clear cell vs. spindle, sarcomatoid

Spindle, sarcomatoid

19

15

1

1

8.3%

7.7%

p = 0.00105; papillary, chromophobe, others vs. spindle, sarcomatoid

Tumor nuclear grade

G1 + G2

206

94

56

12

53.9%

3.9%

p = 0.00215

G3

75

42

12

2

37.1%

6.7%

 

Capsular status

       

Non-invasive

114

55

34

5

52.5%

5.2%

p = 0.00207; non-invasive vs. invasive

Invasive

43

30

6

2

28.4%

7.6%

p = 0.02827; incvasive vs. unknown

Unknown

135

62

28

7

50.2%

5.1%

 

RV/IVC wall invasion

Non-invasive

133

52

39

6

59.5%

4.8%

p = 0.00000; non-invasive vs. invasive

Invasive

78

51

15

6

33.5%

6.2%

p = 0.00107; non-invasive vs. unknown

Unknown

81

44

14

2

41.3%

6.4%

 

Tumor thrombus classification 1

Renal vein, infrahepatic IVC extension

253

119

63

12

50.9%

3.6%

p = 0.05890

Suprahepatic, intracardial IVC, intracardiac extension

31

22

4

2

28.7%

9.4%

 

Tumor thrombus classification 2

Renal vein extension

152

66

41

5

55.1%

4.5%

p = 0.02410; renal vein vs. suprahepatic IVC-intracardiac

Infrahepatic IVC extension

101

53

22

7

44.3%

5.9%

ns; any other comparison

Suprahepatic, intracardial IVC, intracardiac extension

31

22

4

2

28.7%

9.4%

 

Tumor thrombus classification 3

Renal vein extension

152

66

41

5

55.1%

4.5%

p = 0.02883

Infrahepatic, suprahepatic, intracardial IVC, intracardiac extension

132

75

26

9

40.6%

5.0%

 
  1. surgical category 1; radical nephrectomy and complete resection of thrombus without metastasis, surgical category 2; radical nephrectomy and complete resection of thrombus with metastases that has undergone a cytoreductive surgery, surgical category 3; radical nephrectomy and complete resection of thrombus with unresected metastases, surgical category 4; radical nephrectomy and incomplete resection of thrombus regardless of metastatic status, surgical category 5; abandoned operation.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us