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Table 2 Correlations of operative and metastatic status/management with clinicopathologic features of renal cell carcinoma extending into venous system

From: Impacts of clinicopathologic and operative factors on short-term and long-term survival in renal cell carcinoma with venous tumor thrombus extension: a multi-institutional retrospective study in Japan

Variables Operative status of RCC extending to the venous system and metastatic status/management Statistical significance (chi-square test or Mann–Whitney U test)
Radical nephrectomy and complete resection of thrombus Radical nephrectomy and incomplete resection of thrombus regardless of metastatic status Abandoned operation
Without metastasis Existing metastasis and undergoing cytoreductive operation With unresected metastases   
  Surgical category 1 Surgical category 2 Surgical category 3 Surgical category 4 Surgical category 5  
n 196 11 66 8 11  
Age (years)
Mean ± SD 63.0 ± 11.0 57.5 ± 9.1 61.7 ± 9.8 54.3 ± 5.8 66.8 ± 13.8 p < 0.05; surgical category 4 vs. surgical category 1, 3, 5
Performance status (n)
0 143 7 43 4 0 p < 0.05: surgical category 1, 2, 3 vs. surgical category 5 surgical category 1 vs. surgical category 4
1 22 2 10 1 4
2 6 1 5 0 2
3 2 0 3 1 1
Unknown 23 1 5 2 4  
Tumor size classification (n)
<4 cm 20 0 5 0 0 n.s.
4-7 cm 48 1 19 3 2
>7 cm 119 10 40 5 5
Unknown 9 0 2 0 4  
Perinephric fat invasion (n)
No 86 3 20 5 0 p < 0.05: surgical category 1 vs. surgical category 2, 3
Yes 22 4 16 1 0
Unknown 88 4 30 2 11  
Tumor nuclear grade (n)
G1 18 1 5 3 0 n.s.
G2 129 7 42 1 0
G3 48 3 19 4 0
Unknown 1 0 0 0 11  
Histopathologic category (n)
Clear cell 144 10 48 4 0 p < 0.05; : surgical category 1, 2, 3, 4 vs. surgical category 5 surgical category 3 vs. surgical category 4
Papillary, chromophobe, others 42 1 14 1 9
Spindle, sarcomatoid 10 0 4 3 2