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Table 1 Clinicopathologic features of renal cell carcinoma extending into the venous system stratified by level of tumor thrombus

From: Impacts of clinicopathologic and operative factors on short-term and long-term survival in renal cell carcinoma with venous tumor thrombus extension: a multi-institutional retrospective study in Japan

 

Level of tumor thrombus

Statistical significance (chi-square test or Mann–Whitney U test)

Variables

Intra-renal vein

Infrahepatic IVC

Suprahepatic IVC

Intrapericardial IVC/ intracardiac extension

Unknown

Total

n

148

101

20

11

8

292

 

Gender (n)

Male

108

80

15

7

7

217

n.s.

Female

44

21

5

4

1

75

 

Age (years)

Mean ± S.D.

63.7 ± 10.8

60.8 ± 10.4

62.3 ± 11.8

60.6 ± 12.5

61.8 ± 11.4

62.4 ± 10.8

n.s.

Performance status (n)

0

105

73

11

5

3

197

n.s.

1

18

11

6

2

2

39

2

10

2

1

1

0

14

3

2

4

0

1

0

7

Unknown

17

11

2

2

3

35

 

ESR (mm)

Mean ± S.D.

56.5 ± 44.1

65.4 ± 43.7

81.7 ± 38.6

43.8 ± 57.2

93.3 ± 70.6

62.0 ± 44.6

p < 0.05; intra-renal vein vs. suprahepatic IVC

CRP (ng/ml)

Mean ± S.D.

3.7 ± 4.9

4.0 ± 5.7

5.3 ± 5.6

1.7 ± 1.4

7.2 ± 10.0

3.9 ± 5.4

n.s.

IAP (ug/ml)

Mean ± S.D.

796.9 ± 420.5

794.4 ± 328.2

1020.4 ± 438.7

828.2 ± 372.9

789 ± 475

813.2 ± 391.4

p < 0.05; intra-renal vein, infrahepatic IVC vs. suprahepatic IVC

Tumor size classification (n)

<4 cm

17

5

1

2

0

25

n.s.

4-7 cm

40

22

5

4

2

73

>7 cm

90

70

11

4

4

179

Unknown

5

4

3

1

2

15

 

Tumor location (n)

Right

72

67

12

9

5

165

n.s.

Left

76

33

8

2

1

120

Bilateral

2

1

0

0

0

3

Missing data

2

0

0

0

2

4

 

Perinephric fat invasion (n)

No

56

38

12

5

3

114

n.s.

Yes

21

17

3

1

1

43

Unknown

75

46

5

5

4

135

 

Regional lymph node involvement (n)

No

74

29

10

4

1

118

n.s.

Yes

27

23

3

2

6

61

Unknown

51

49

7

5

1

113

 

Distant metastases (n)

No

100

60

12

8

3

183

n.s.

Yes

47

32

4

3

5

91

Unknown

5

9

4

0

0

18

 

Tumor nuclear grade (n)

G1

15

9

2

1

0

27

n.s.

G2

103

52

14

6

4

179

G3

29

38

4

3

1

75

Unknown

5

2

0

1

3

11

 

Histopathologic category (n)

Clear cell

112

67

17

7

3

206

n.s.

Papillary, chromophobe, others

28

29

3

4

3

67

Spindle, sarcomatoid

12

5

0

0

2

19