Table 6 Association between NLR, clinical and pathology features and any recurrence with death due to other causes as a competing risk
| Â | Number of patients | Number of recurrences | Bivariate association HR, (95% CI), Wald p | Multivariable association HR, (95% CI), Wald p |
|---|---|---|---|---|
Neutrophil/lymphocyte ratio | 311 | 108 | 1.04 (0.97–1.11) 0.241 | 0.99 (0.90–1.08) 0.772 |
Male | 171 | 56 | 0.81 (0.56–1.19) 0.291 | -- |
Female | 138 | 52 | ||
Age ≥ 75 years | 98 | 40 | 1.31 (0.88–1.94) 0.178 | -- |
Age < 75 years | 211 | 68 | ||
Rectal tumor | 124 | 46 | 1.09 (0.74–1.60) 0.676 | -- |
Colonic tumor | 185 | 62 | ||
Tumor diameter ≥ 5cm | 134 | 49 | 1.21 (0.82–1.77) 0.335 | -- |
< 5cm | 175 | 59 | ||
Mucinous or signet ring | 32 | 15 | 1.45 (0.87–2.42) 0.153 | -- |
No | 277 | 93 | ||
Direct spread beyond muscularis propria | 260 | 97 | 2.14 (1.15–4.00) 0.017 | -- |
49 | 11 | |||
No | ||||
Apical node involved | 29 | 15 | 1.95 (1.10–3.45) 0.022 | -- |
No | 280 | 93 | ||
≥ 4 nodes involved | 98 | 47 | 1.89 (1.29–2.77) 0.001 | -- |
No | 211 | 61 | ||
≥ 40% of nodes involved | 56 | 32 | 2.36 (1.56–3.55) <0.001 | 1.87 (1.17–3.01) 0.009 |
No | 255 | 76 | ||
Poorly differentiated | 64 | 34 | 2.09 (1.39–3.13) <0.001 | 1.66 (1.07–2.57) 0.024 |
No | 247 | 74 | ||
Venous invasion | 61 | 26 | 1.50 (0.95–2.36) ).080 | -- |
No | 248 | 82 | ||
Free serosal surface involved | 73 | 41 | 2.66 (1.80–3.95) <0.001 | 1.83 (1.18–2.84) 0.007 |
No | 236 | 67 | ||
Adjacent structure infiltrated | 22 | 16 | 3.86 (2.19–6.79) <0.001 | 2.93 (1.58–5.44) 0.011 |
No | 287 | 92 | ||
Postoperative chemotherapy | 195 | 71 | 1.18 (0.79–1.77) 0.407 | -- |
No | 114 | 37 | Â | Â |