Table 1 Altered expression of the 16 genes in lung cancer tissues compared with their adjacent nonmalignant lung tissues using quantitative RT-PCR (q-RT-PCR)
Gene | Library | Percentage | Main Functions | References |
|---|---|---|---|---|
GPX3 | RSL | ↓ 85% (29/34)# | Detoxification of hydrogen peroxide. Suppresses prostate cancer growth and metastasis. | Brigelius et al. (2012) Yu et al. (2007) |
TIMP3 | RSL | ↓ 85% (29/34) | Degradation of the extracellular matrix. A mediator for checking inflammation. Cell invasion, proliferation, and death. | Gomez et al. (1997) Shao et al. (2012) Baker et al. (1998) |
CD9 | RSL & FSL | ↑ 41% (14/34) | Functions in many cellular processes including differentiation, adhesion, and signal transduction. Suppression of cancer cell motility and metastasis. | Chen et al. (2011) Yamazaki et al. (2011) |
DDR1 | FSL | ↑ 74% (25/34) | Communication of cells with their microenvironment. Regulation of cell growth, differentiation and metabolism. | Valencia et al. (2012) Ruiz et al. (2011) Kim et al. (2011) |
HSP90B1 | FSL | ↑ 82% (28/34) | Molecular chaperones with roles in stabilizing and folding other proteins. Association with a variety of pathogenic states. | Sanz-Pamplona et al. (2011) Eletto et al. (2010) Calderwood et al. (2007) |
FOXA2 | FSL | ↑ 29% (10/34) | Transcriptional activators for liver-specific genes. Maintenance of glucose and lipid homeostasis. Suppressor of tumor metastasis by inhibition of EMT. | Rausa et al. (2004) Wolfrum et al. (2004) Tang et al. (2011) |
SDC1 | FSL | ↑ 82% (28/34) | Regulation of cell proliferation, cell migration and cell-matrix interactions. | Schmedt et al. (2012) Zong et al. (2011) |
C4BPA | FSL | ↑ 35% (12/34) | Activation of the complement cascade. | Arenzana et al. (1995) Fraczek et al. (2010) |
SCGB3A1 | FSL | ↑ 56% (19/34) | Inhibition of cell growth and invasion. | Haakensen et al. (2011) Tomita et al. (2009) |
RPSA | FSL | ↑ 65% (22/34) | Implication of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. | Qiao et al. (2009) Zidane et al. (2012) |
ERGIC3 | FSL | ↑ 76% (47/62) | Regulation of cell growth and endoplasmic reticulum stress-induced cell death. Protein transport through the early secretory pathway. | Zhang et al. (2012) Nishikawa et al. (2007) Otte et al. (2002) |
DDX58 | FSL | ↑ 47% (29/62) | Regulation of immune response. | Liu et al. (2011) Aida et al. (2011) |
CCNDBP1 | FSL | ↑ 47% (29/62) | Inhibition of cell cycle. Suppression of tumorigenesis. | Lee et al. (2010) Ma et al. (2007) |
TMSB4X | FSL | ↑ 37% (23/62) | Regulation of actin polymerization. Implication of cell proliferation, migration, and differentiation | Moon et al. (2010) Selmi et al.(2012) |
CXCL17 | FSL | ↑ 45% (28/62) | Anti-inflammatory factor. Promotion of angiogenesis. | Lee et al. (2012) Matsui et al. (2012) |
LPCAT1 | FSL | ↑ 47% (29/62) | Catalyzing the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis. Promotion of cell growth. | Nakanishi et al. (2006) Soupene et al. (2012) Mansilla et al. (2009) |