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Table 1 Altered expression of the 16 genes in lung cancer tissues compared with their adjacent nonmalignant lung tissues using quantitative RT-PCR (q-RT-PCR)

From: Suppression subtractive hybridization identified differentially expressed genes in lung adenocarcinoma: ERGIC3as a novel lung cancer-related gene

Gene Library Percentage Main Functions References
GPX3 RSL ↓ 85% (29/34)# Detoxification of hydrogen peroxide. Suppresses prostate cancer growth and metastasis. Brigelius et al. (2012) Yu et al. (2007)
TIMP3 RSL ↓ 85% (29/34) Degradation of the extracellular matrix. A mediator for checking inflammation. Cell invasion, proliferation, and death. Gomez et al. (1997) Shao et al. (2012) Baker et al. (1998)
CD9 RSL & FSL ↑ 41% (14/34) Functions in many cellular processes including differentiation, adhesion, and signal transduction. Suppression of cancer cell motility and metastasis. Chen et al. (2011) Yamazaki et al. (2011)
DDR1 FSL ↑ 74% (25/34) Communication of cells with their microenvironment. Regulation of cell growth, differentiation and metabolism. Valencia et al. (2012) Ruiz et al. (2011) Kim et al. (2011)
HSP90B1 FSL ↑ 82% (28/34) Molecular chaperones with roles in stabilizing and folding other proteins. Association with a variety of pathogenic states. Sanz-Pamplona et al. (2011) Eletto et al. (2010) Calderwood et al. (2007)
FOXA2 FSL ↑ 29% (10/34) Transcriptional activators for liver-specific genes. Maintenance of glucose and lipid homeostasis. Suppressor of tumor metastasis by inhibition of EMT. Rausa et al. (2004) Wolfrum et al. (2004) Tang et al. (2011)
SDC1 FSL ↑ 82% (28/34) Regulation of cell proliferation, cell migration and cell-matrix interactions. Schmedt et al. (2012) Zong et al. (2011)
C4BPA FSL ↑ 35% (12/34) Activation of the complement cascade. Arenzana et al. (1995) Fraczek et al. (2010)
SCGB3A1 FSL ↑ 56% (19/34) Inhibition of cell growth and invasion. Haakensen et al. (2011) Tomita et al. (2009)
RPSA FSL ↑ 65% (22/34) Implication of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Qiao et al. (2009) Zidane et al. (2012)
ERGIC3 FSL ↑ 76% (47/62) Regulation of cell growth and endoplasmic reticulum stress-induced cell death. Protein transport through the early secretory pathway. Zhang et al. (2012) Nishikawa et al. (2007) Otte et al. (2002)
DDX58 FSL ↑ 47% (29/62) Regulation of immune response. Liu et al. (2011) Aida et al. (2011)
CCNDBP1 FSL ↑ 47% (29/62) Inhibition of cell cycle. Suppression of tumorigenesis. Lee et al. (2010) Ma et al. (2007)
TMSB4X FSL ↑ 37% (23/62) Regulation of actin polymerization. Implication of cell proliferation, migration, and differentiation Moon et al. (2010) Selmi et al.(2012)
CXCL17 FSL ↑ 45% (28/62) Anti-inflammatory factor. Promotion of angiogenesis. Lee et al. (2012) Matsui et al. (2012)
LPCAT1 FSL ↑ 47% (29/62) Catalyzing the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis. Promotion of cell growth. Nakanishi et al. (2006) Soupene et al. (2012) Mansilla et al. (2009)
  1. ↓: Down-regulation of the genes in lung cancer tissues compared with their adjacent nonmalignant lung tissues; ↑: Up-regulation of the genes in lung cancer tissues compared with their adjacent nonmalignant lung tissues; #: Number of cases applicable/total number of cases examined.