| | |
OS
|
RFS
|
SAR
|
|---|
|
Factor
|
Comparison
|
P-value
|
HR (95% CI)
|
P-value
|
HR (95% CI)
|
P-value
|
HR (95% CI)
|
|---|
|
MSI
|
MSI-H vs MSS
|
0.0002
|
0.45 (0.30,0.69)
|
< 0.0001
|
0.48 (0.34,0.68)
|
0.9643
|
0.99 (0.65,1.52)
|
|
Site
|
Left vs Right
|
0.3143
|
0.89 (0.72,1.11)
|
0.2123
|
1.13 (0.93,1.36)
|
<0.0001
|
0.59 (0.47, 0.73)
|
|
Grade
|
G3,4 vs G1,2
|
0.0018
|
1.63 (1.29,2.23)
|
0.0012
|
1.56 (1.19,2.04)
|
0.0387
|
1.38 (1.01,1.88)
|
|
T stage
|
T3 vs T1,2
|
0.0634
|
1.76 (0.96,3.22)
|
0.0629
|
1.58 (0.97,2.58)
|
0.1399
|
1.57 (0.86,2.88)
|
| |
T4 vs T1,2
|
0.0002
|
3.06 (1.63,5.74)
|
< 0.0001
|
2.69 (1.61,4.48)
|
0.0680
|
1.78 (0.95,3.35)
|
|
N stage
|
N1 vs N0
|
< 0.0001
|
1.91 (1.38,2.65)
|
< 0.0001
|
1.78 (1.36, 2.32)
|
0.9809
|
0.98 (0.71,1.35)
|
| |
N2 vs N0
|
< 0.0001
|
4.51 (3.28,6.21)
|
< 0.0001
|
4.06 (3.11,5.29)
|
0.1498
|
1.24 (0.90,1.71)
|
|
BRAF
|
BRAF mut vs WT2
|
0.0004
|
1.92 (1.33,2.78)
|
0.0832
|
1.35 (0.96,1.89)
|
< 0.0001
|
2.56 (1.75,3.70)
|
| |
BRAF mut vs BRAF wt
|
0.0009
|
1.78 (1.26,2.53)
|
0.1174
|
1.30 (0.94,1.81)
|
< 0.0001
|
2.48 (1.74,3.53)
|
|
KRAS
|
KRAS mut vs WT2
|
0.1461
|
1.20 (0.93,1.54)
|
0.4410
|
1.09 (0.88,1.33)
|
0.1755
|
1.18 (0.93,1.52)
|
| |
KRAS mut vs KRAS wt
|
0.4826
|
1.09 (0.86,1.37)
|
0.7245
|
1.04 (0.85,1.27)
|
0.7222
|
1.04 (0.82,1.32)
|
