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Table 1 Univariate analysis of the prognostic factors in the whole CRC population

From: Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer

   OS RFS SAR
Factor Comparison P-value HR (95% CI) P-value HR (95% CI) P-value HR (95% CI)
MSI MSI-H vs MSS 0.0002 0.45 (0.30,0.69) < 0.0001 0.48 (0.34,0.68) 0.9643 0.99 (0.65,1.52)
Site Left vs Right 0.3143 0.89 (0.72,1.11) 0.2123 1.13 (0.93,1.36) <0.0001 0.59 (0.47, 0.73)
Grade G3,4 vs G1,2 0.0018 1.63 (1.29,2.23) 0.0012 1.56 (1.19,2.04) 0.0387 1.38 (1.01,1.88)
T stage T3 vs T1,2 0.0634 1.76 (0.96,3.22) 0.0629 1.58 (0.97,2.58) 0.1399 1.57 (0.86,2.88)
  T4 vs T1,2 0.0002 3.06 (1.63,5.74) < 0.0001 2.69 (1.61,4.48) 0.0680 1.78 (0.95,3.35)
N stage N1 vs N0 < 0.0001 1.91 (1.38,2.65) < 0.0001 1.78 (1.36, 2.32) 0.9809 0.98 (0.71,1.35)
  N2 vs N0 < 0.0001 4.51 (3.28,6.21) < 0.0001 4.06 (3.11,5.29) 0.1498 1.24 (0.90,1.71)
BRAF BRAF mut vs WT2 0.0004 1.92 (1.33,2.78) 0.0832 1.35 (0.96,1.89) < 0.0001 2.56 (1.75,3.70)
  BRAF mut vs BRAF wt 0.0009 1.78 (1.26,2.53) 0.1174 1.30 (0.94,1.81) < 0.0001 2.48 (1.74,3.53)
KRAS KRAS mut vs WT2 0.1461 1.20 (0.93,1.54) 0.4410 1.09 (0.88,1.33) 0.1755 1.18 (0.93,1.52)
  KRAS mut vs KRAS wt 0.4826 1.09 (0.86,1.37) 0.7245 1.04 (0.85,1.27) 0.7222 1.04 (0.82,1.32)