OS | RFS | SAR | |||||
---|---|---|---|---|---|---|---|
Factor | Comparison | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) |
MSI | MSI-H vs MSS | 0.0002 | 0.45 (0.30,0.69) | < 0.0001 | 0.48 (0.34,0.68) | 0.9643 | 0.99 (0.65,1.52) |
Site | Left vs Right | 0.3143 | 0.89 (0.72,1.11) | 0.2123 | 1.13 (0.93,1.36) | <0.0001 | 0.59 (0.47, 0.73) |
Grade | G3,4 vs G1,2 | 0.0018 | 1.63 (1.29,2.23) | 0.0012 | 1.56 (1.19,2.04) | 0.0387 | 1.38 (1.01,1.88) |
T stage | T3 vs T1,2 | 0.0634 | 1.76 (0.96,3.22) | 0.0629 | 1.58 (0.97,2.58) | 0.1399 | 1.57 (0.86,2.88) |
T4 vs T1,2 | 0.0002 | 3.06 (1.63,5.74) | < 0.0001 | 2.69 (1.61,4.48) | 0.0680 | 1.78 (0.95,3.35) | |
N stage | N1 vs N0 | < 0.0001 | 1.91 (1.38,2.65) | < 0.0001 | 1.78 (1.36, 2.32) | 0.9809 | 0.98 (0.71,1.35) |
N2 vs N0 | < 0.0001 | 4.51 (3.28,6.21) | < 0.0001 | 4.06 (3.11,5.29) | 0.1498 | 1.24 (0.90,1.71) | |
BRAF | BRAF mut vs WT2 | 0.0004 | 1.92 (1.33,2.78) | 0.0832 | 1.35 (0.96,1.89) | < 0.0001 | 2.56 (1.75,3.70) |
BRAF mut vs BRAF wt | 0.0009 | 1.78 (1.26,2.53) | 0.1174 | 1.30 (0.94,1.81) | < 0.0001 | 2.48 (1.74,3.53) | |
KRAS | KRAS mut vs WT2 | 0.1461 | 1.20 (0.93,1.54) | 0.4410 | 1.09 (0.88,1.33) | 0.1755 | 1.18 (0.93,1.52) |
KRAS mut vs KRAS wt | 0.4826 | 1.09 (0.86,1.37) | 0.7245 | 1.04 (0.85,1.27) | 0.7222 | 1.04 (0.82,1.32) |