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Table 5 Univariate and multivariate survival analysis for resected periampullary adenocarcinomas

From: Intestinal-type of differentiation predicts favourable overall survival: confirmatory clinicopathological analysis of 198 periampullary adenocarcinomas of pancreatic, biliary, ampullary and duodenal origin

Parameter

Condition

Median survival (months)

Hazard ratio

Univariate

Multivariate

  

With condition

Without condition

(95% CI)

p

p

All patients (n = 191)

-26-

-

  

Gender

Male

30

25

0.953 (0.641–1.417)

0.812

NI

Age (years)1

> 67

26

27

1.050 (0.706–1.561)

0.811

NI

Distant metastasis

Yes

11

27

2.044 (0.892–4.688)

0.091

NI

Neoadjuvant tx

Yes

25

26

1.536 (0.741–3.182)

0.248

NI

PVR

Yes

25

27

1.640 (1.068–2.517)

0.024

0.510

Tumor size (mm)1

> 25

26

26

1.069 (0.699–1.635)

0.759

NI

Tumor grade

G3/4

17

31

1.808 (1.199–2.726)

0.005

0.075

pT stage

pT3/4

23

41

1.938 (1.160–3.238)

0.012

0.905

pN stage

pN1/2

22

52

1.883 (1.198–2.959)

0.006

0.211

LNR1

> 0.09

20

48

2.291 (1.515–3.465)

0.000

0.019

Lymphangiosis

Present

22

30

1.557 (1.035–2.342)

0.033

0.398

Hemangiosis

Present

12

29

1.900 (1.161–3.109)

0.011

0.384

Perineural invasion

Present

25

29

1.322 (0.881–1.984)

0.177

NI

Precursor lesion

Present

NR

25

0.362 (0.175–0.748)

0.006

0.169

Resection margins

Positive

19

37

2.368 (1.551–3.617)

0.000

0.132

Tumor subtype2

See Table 4

1.487 (1.253–1.765)

0.000

0.006

Tumor location2

See Table 4

1.471 (1.175–1.843)

0.001

0.270

CK7 + (%)1

> 90

20

38

1.757 (1.161–2.657)

0.008

0.869

CK20 + (%)1

> 0

29

23

0.311 (0.538–1.218)

0.311

NI

CDX2 + (%)1

> 10

48

20

0.562 (0.368–0.858)

0.008

0.767

  1. Survival estimates are derived from Kaplan-Meyer method, perioperative deaths (n = 7) were excluded, univariate / multivariate p is derived from two-sided Cox regression in a proportional hazards model.
  2. Abbreviations: CK cytokeratin, CI confidence interval, + positive. 1 cut-off at overall median value, 2 defined as ordinal variable according to decreasing median survival as indicated in Table 2, pos positive, tx therapy, PVR portal venous resection, NR not reached.