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Table 5 Prevalence of symptoms and tumor markers as related to tumor malignancy and stage

From: Symptoms, CA125 and HE4 for the preoperative prediction of ovarian malignancy in Brazilian women with ovarian masses

 

Malignant

Benign

OR (95% CI)

Stage I

Stage II-IV

All

(n = 116)

All malignant

Stage I

Stage II-IV

Stage II-IV

(n = 32)

(n = 28)

(n = 60)

vs. benign

vs. benign

vs. benign

vs. stage I

Cluster

%

%

%

%

    

Abdomen

72

64

68

31

4.7 (2.4 to 9.4)

5.7 (2.4 to 13.5)

4.0 (1.7 to 9.5)

0.7 (0.2 to 2.1)

Pain

44

68

55

22

4.2 (2.1 to 8.2)

2.7 (1.6 to 6.1)

7.3 (2.9 to 18.1)

2.7 (0.9 to 7.8)

Eating

37

54

45

12

6.0 (2.8 to 12.7)

4.4 (1.8 to 10.8)

8.4 (3.3 to 21.3)

1.9 (0.7 to 5.4)

Symptom index (SI)

78

79

78

40

5.5 (2.7 to 11.3)

5.4 (2.2 to 13.6)

5.6 (2.1 to 14.8)

1.0 (0.3 to 3.5)

CA125

47

85

65

24

5.7 (2.8 to 12.2)

3.5 (1.5 to 9.2)

18.4 (5.4 to 79.4)

5.1 (1.3 to 25.1)

HE4

34

86

58

15

7.6 (3.7 to 15.6)

2.8 (1.2 to 6.9)

32.7 (10.1 to 105.4)

11.4 (3.2 to 41.4)

ROMA PI

34

82

57

12

9.5 (4.4 to 20.3)

3.8 (1.5 to 9.6)

33.5 (11.0 to 102.4)

8.7 (2.6 to 29.5)

  1. Symptom index (SI) = presence of at least one of the symptoms included in the clusters abdomen, pain and/or eating.
  2. Cutoff points in premenopausal women: CA125 = 69.8 U/ml, HE4 = 41.6 pMol/L, ROMA predictive index (PI) = > 5.01%. In postmenopausal women: CA125 = 21.7 U/L, HE4 = 96.6 pMol/L, ROMA-PI > 18.2%. PPV positive predictive value, NPV negative predictive value.