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Table 2 Results of cox regression analyses 1

From: Prognostic impact of tumor infiltrating CD8+ T cells in association with cell proliferation in ovarian cancer patients - a study of the OVCAD consortium

A) Prognostic values of various parameters on overall survival
N = 197 (93 events) Univariate Multivariable
  HR (CI95%) p HR (CI95%) p
Age (continuous, per decade) 1.35 (1.14-1.60) <0.001 1.26 (1.07-1.48) 0.006
FIGO (ordinal, per stage) 2.22 (1.44-3.42) <0.001 2.18 (1.38-3.45) <0.001
Residual tumor (yes vs. no) 2.01 (1.32-3.06) 0.001 1.87 (1.21-2.88) 0.005
CD8+ cell infiltration (continuous, per doubling) 0.86 (0.77-0.96) 0.006 0.82 (0.73-0.92) <0.001
Ki67+ tumor cells (<5% vs. ≥5%) 3.27 (1.57-6.83) 0.002 3.34 (1.59-7.04) 0.001
B) Prognostic values of various parameters on progression-free survival
N = 180 (139 events) Univariate Multivariable
  HR (CI95%) p HR (CI95%) p
Age (continuous, per decade) 1.18 (1.03-1.34) 0.016 1.08 (0.94-1.23) 0.268
FIGO (ordinal, per stage) 2.51 (1.72-3.67) <0.001 2.19 (1.43-3.35) <0.001
Residual tumor (yes vs. no) 2.07 (1.44-2.98) <0.001 1.64 (1.11-2.43) 0.013
CD8 cell infiltration (continuous, per doubling) 0.97 (0.89-1.05) 0.447 0.92 (0.84-1.01) 0.074
Ki67 (<5% vs. ≥5%) 1.63 (0.76-3.49) 0.209 1.51 (0.69-3.28) 0.299
  1. 1HR and p values of statistically significant parameters presented in bold.