TY - JOUR AU - Jang, Ji-Young AU - Lee, Jong-Kuen AU - Jeon, Yoon-Kyung AU - Kim, Chul-Woo PY - 2013 DA - 2013/09/17 TI - Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization JO - BMC Cancer SP - 421 VL - 13 IS - 1 AB - Tumor-associated macrophages (TAM) play an important role in tumor microenvironment. Particularly, M2 macrophages contribute to tumor progression, depending on the expression of NF-κB. Tumor-derived exosomes can modulate tumor microenvironment by transferring miRNAs to immune cells. Epigallocatechin gallate (EGCG) has well known anti-tumor effects; however, no data are available on the influence of EGCG on communication with cancer cells and TAM. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-13-421 DO - 10.1186/1471-2407-13-421 ID - Jang2013 ER -