Figure 1

The signature profile of PAM50 gene expression in SK-BR-3 cells. The expression profile of PAM50 genes (40 matching genes) from microarray data [32] in SK-BR-3 cells treated with vehicle, DHA, CCM or DHA + CCM were used to compare the signature profile of 41 genes represented on the U133A array system, as reported by Creighton [46], to classify tumors into basal-like, Her-2-enriched, luminal A, luminal B, and “normal-like.” The expression profile of untreated cells (control) resembled the ER^-, Her-2-enriched profile, whereas the expression profile of cells treated with DHA + CCM more closely resembled the “normal-like” profile.